FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077343800> ?p ?o ?g. }

• W2077343800 endingPage "310" @default.
• W2077343800 startingPage "297" @default.
• W2077343800 abstract "Inhibitory effects of sustained delivery systems (microcapsules) of the modern antagonist of luteinizing hormone-releasing hormone [Ac-D-Nal(2)1, D-Phe(4Cl)2, D-Pal(3)3, D-Cit6, D-Ala10]LH-RH (SB-75) or the potent somatostatin analog D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2 (RC-160) were investigated in the Dunning R-3327H rat prostate cancer model. In the first experiment, the treatment was started 4 months after tumor transplantation, when the tumors measured approximately 2 cm3. Tumor volumes and weights were significantly reduced by SB-75 microcapsules releasing 48 micrograms/day or RC-160 microcapsules releasing 38 micrograms/day given alone, as compared with the control. The combination of these two analogs showed a synergistic effect. In the second experiment, the treatment was started 7 months after tumor transplantation, when the tumors were well developed and measured about 16 cm3. In addition to a significant reduction in volume, weight, and growth rate of tumors, histological signs of tumor regression were found in the groups treated with SB-75 microcapsules releasing 72 micrograms/day given alone or in combination with RC-160 microcapsules releasing 76 micrograms/day, but not with RC-160 alone. No synergistic effect of the combination therapy was found in the second experiment. Serum testosterone levels decreased to undetectable levels and LH levels were also diminished within 2 weeks by administration of SB-75 alone or in combination with RC-160. In both experiments, the weights of testes, ventral prostate, and seminal vesicles were greatly reduced by administration of SB-75 alone or in combination with RC-160. Our results suggest that the combined therapy with microcapsules of SB-75 and RC-160, started soon after the diagnosis of prostate cancer is made, could improve therapeutic response." @default.
• W2077343800 created "2016-06-24" @default.
• W2077343800 creator A5013036085 @default.
• W2077343800 creator A5029989187 @default.
• W2077343800 creator A5034880428 @default.
• W2077343800 creator A5047212274 @default.
• W2077343800 creator A5063861158 @default.
• W2077343800 creator A5065215059 @default.
• W2077343800 date "1992-01-01" @default.
• W2077343800 modified "2023-10-18" @default.
• W2077343800 title "Effect of microcapsules of luteinizing hormone-releasing hormone antagonist SB-75 and somatostatin analog RC-160 on endocrine status and tumor growth in the dunning R-3327H rat prostate cancer model" @default.
• W2077343800 cites W111083711 @default.
• W2077343800 cites W1894512109 @default.
• W2077343800 cites W1964608963 @default.
• W2077343800 cites W1967675137 @default.
• W2077343800 cites W1970185366 @default.
• W2077343800 cites W1972020194 @default.
• W2077343800 cites W1986451811 @default.
• W2077343800 cites W1997662342 @default.
• W2077343800 cites W2002242830 @default.
• W2077343800 cites W2016514222 @default.
• W2077343800 cites W2022690114 @default.
• W2077343800 cites W2022766362 @default.
• W2077343800 cites W2026829967 @default.
• W2077343800 cites W2038243639 @default.
• W2077343800 cites W2043813981 @default.
• W2077343800 cites W2046051991 @default.
• W2077343800 cites W2050325088 @default.
• W2077343800 cites W2051556053 @default.
• W2077343800 cites W2052944345 @default.
• W2077343800 cites W2056727688 @default.
• W2077343800 cites W2059295683 @default.
• W2077343800 cites W2063455074 @default.
• W2077343800 cites W2078230286 @default.
• W2077343800 cites W2078939599 @default.
• W2077343800 cites W2087107375 @default.
• W2077343800 cites W2091744333 @default.
• W2077343800 cites W2092235725 @default.
• W2077343800 cites W2137753873 @default.
• W2077343800 cites W2407797352 @default.
• W2077343800 doi "https://doi.org/10.1002/pros.2990200405" @default.
• W2077343800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1351672" @default.
• W2077343800 hasPublicationYear "1992" @default.
• W2077343800 type Work @default.
• W2077343800 sameAs 2077343800 @default.
• W2077343800 citedByCount "22" @default.
• W2077343800 countsByYear W20773438002013 @default.
• W2077343800 crossrefType "journal-article" @default.
• W2077343800 hasAuthorship W2077343800A5013036085 @default.
• W2077343800 hasAuthorship W2077343800A5029989187 @default.
• W2077343800 hasAuthorship W2077343800A5034880428 @default.
• W2077343800 hasAuthorship W2077343800A5047212274 @default.
• W2077343800 hasAuthorship W2077343800A5063861158 @default.
• W2077343800 hasAuthorship W2077343800A5065215059 @default.
• W2077343800 hasConcept C121608353 @default.
• W2077343800 hasConcept C126322002 @default.
• W2077343800 hasConcept C134018914 @default.
• W2077343800 hasConcept C170493617 @default.
• W2077343800 hasConcept C185592680 @default.
• W2077343800 hasConcept C2776235491 @default.
• W2077343800 hasConcept C2776297358 @default.
• W2077343800 hasConcept C2776885963 @default.
• W2077343800 hasConcept C2777886879 @default.
• W2077343800 hasConcept C2778575703 @default.
• W2077343800 hasConcept C2779279991 @default.
• W2077343800 hasConcept C2780192828 @default.
• W2077343800 hasConcept C2911091166 @default.
• W2077343800 hasConcept C46699223 @default.
• W2077343800 hasConcept C71315377 @default.
• W2077343800 hasConcept C71924100 @default.
• W2077343800 hasConceptScore W2077343800C121608353 @default.
• W2077343800 hasConceptScore W2077343800C126322002 @default.
• W2077343800 hasConceptScore W2077343800C134018914 @default.
• W2077343800 hasConceptScore W2077343800C170493617 @default.
• W2077343800 hasConceptScore W2077343800C185592680 @default.
• W2077343800 hasConceptScore W2077343800C2776235491 @default.
• W2077343800 hasConceptScore W2077343800C2776297358 @default.
• W2077343800 hasConceptScore W2077343800C2776885963 @default.
• W2077343800 hasConceptScore W2077343800C2777886879 @default.
• W2077343800 hasConceptScore W2077343800C2778575703 @default.
• W2077343800 hasConceptScore W2077343800C2779279991 @default.
• W2077343800 hasConceptScore W2077343800C2780192828 @default.
• W2077343800 hasConceptScore W2077343800C2911091166 @default.
• W2077343800 hasConceptScore W2077343800C46699223 @default.
• W2077343800 hasConceptScore W2077343800C71315377 @default.
• W2077343800 hasConceptScore W2077343800C71924100 @default.
• W2077343800 hasIssue "4" @default.
• W2077343800 hasLocation W20773438001 @default.
• W2077343800 hasLocation W20773438002 @default.
• W2077343800 hasOpenAccess W2077343800 @default.
• W2077343800 hasPrimaryLocation W20773438001 @default.
• W2077343800 hasRelatedWork W1970208811 @default.
• W2077343800 hasRelatedWork W1991634850 @default.
• W2077343800 hasRelatedWork W2047880909 @default.
• W2077343800 hasRelatedWork W2051270818 @default.
• W2077343800 hasRelatedWork W2055134215 @default.
• W2077343800 hasRelatedWork W2061617182 @default.
• W2077343800 hasRelatedWork W2157478148 @default.

• next