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- W2077344733 abstract "Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease with a poor prognosis. With advances in understanding of its pathogenesis, antifibrotic agents were proven to be effective. Pirfenidone slows the progression of IPF and fortunately it has resulted in survival benefit.Areas covered: Randomized clinical trials of pirfenidone showed a significant reduction in the decline of lung function. In 2014 May, the pooled analysis of the results of the Assessment of Pirfenidone to Confirm Efficacy and Safety in IPF trial combined with CAPACITY trials revealed a mortality benefit, which was the first in the history of IPF.Expert opinion: Pirfenidone is slow acting and is not approved for severe patients except in Japan. The prevalence of its use and compliance are current issues. An important task after marketing is to identify appropriate candidates for its use and the correct time of initiation, in addition to establishing criteria to evaluate its therapeutic benefits. Furthermore, it is desirable to widen the approval of this novel drug for other fibrotic diseases. We need to investigate other unknown therapeutic benefits associated with prognosis other than inhibition of declines in vital capacity." @default.
- W2077344733 created "2016-06-24" @default.
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- W2077344733 date "2015-04-17" @default.
- W2077344733 modified "2023-09-24" @default.
- W2077344733 title "Pirfenidone: an orphan drug for treating idiopathic pulmonary fibrosis" @default.
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- W2077344733 doi "https://doi.org/10.1517/21678707.2015.1029453" @default.
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