Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077348013> ?p ?o ?g. }
- W2077348013 abstract "Iptakalim hydrochloride (Ipt), a novel antihypertensive drug, exhibits K(ATP) channel activation. Here, we report that Ipt remarkably protects cells against neurotoxin-induced glutamate transporter dysfunction in in vitro and in vivo models. Chronic exposure of cultured PC12 cells to neurotoxins, such as 6-OHDA, MPP+, or rotenone, decreased overall [3H]-glutamate uptake in a concentration-dependent manner. Pre-treatment using 10 microM Ipt significantly protected cells against neurotoxin-induced glutamate uptake diminishment, and this protection was abolished by the K(ATP) channel blocker glibenclamide (20 microM), suggesting that the protective mechanisms may involve the opening of K(ATP) channels. In 6-OHDA-treated rats (as an in vivo Parkinson's disease model), [3H]-glutamate uptake was significantly lower in synaptosomes isolated from the striatum and cerebral cortex, but not the hippocampus. Pre-conditioning using 10, 50, and 100 microM Ipt significantly restored glutamate uptake impairment and these protections were abolished by blockade of K(ATP) channels. It is concluded that Ipt exhibits substantial protection of cells against neurotoxicity in in vitro and in vivo models. The cellular mechanisms of this protective effect may involve the opening of K(ATP) channels. Collectively, Ipt may serve as a novel and effective drug for PD therapy." @default.
- W2077348013 created "2016-06-24" @default.
- W2077348013 creator A5010394291 @default.
- W2077348013 creator A5024751759 @default.
- W2077348013 creator A5032600833 @default.
- W2077348013 creator A5046543918 @default.
- W2077348013 creator A5062324929 @default.
- W2077348013 creator A5065046382 @default.
- W2077348013 creator A5082255640 @default.
- W2077348013 date "2005-07-01" @default.
- W2077348013 modified "2023-09-23" @default.
- W2077348013 title "Iptakalim hydrochloride protects cells against neurotoxin-induced glutamate transporter dysfunction in in vitro and in vivo models" @default.
- W2077348013 cites W1487720736 @default.
- W2077348013 cites W1519302095 @default.
- W2077348013 cites W1548412131 @default.
- W2077348013 cites W1548478592 @default.
- W2077348013 cites W1568440737 @default.
- W2077348013 cites W1577255033 @default.
- W2077348013 cites W1580449555 @default.
- W2077348013 cites W1775749144 @default.
- W2077348013 cites W1944942244 @default.
- W2077348013 cites W1963487339 @default.
- W2077348013 cites W1964230438 @default.
- W2077348013 cites W1969025481 @default.
- W2077348013 cites W1969783938 @default.
- W2077348013 cites W1970367133 @default.
- W2077348013 cites W1970587959 @default.
- W2077348013 cites W1987474429 @default.
- W2077348013 cites W1992193294 @default.
- W2077348013 cites W1999225281 @default.
- W2077348013 cites W2002099191 @default.
- W2077348013 cites W2006242402 @default.
- W2077348013 cites W2009351843 @default.
- W2077348013 cites W2009987256 @default.
- W2077348013 cites W2013623120 @default.
- W2077348013 cites W2014227627 @default.
- W2077348013 cites W2024353105 @default.
- W2077348013 cites W2026955137 @default.
- W2077348013 cites W2033421414 @default.
- W2077348013 cites W2034832966 @default.
- W2077348013 cites W2037115067 @default.
- W2077348013 cites W2042790831 @default.
- W2077348013 cites W2046407288 @default.
- W2077348013 cites W2048093594 @default.
- W2077348013 cites W2050279035 @default.
- W2077348013 cites W2050608247 @default.
- W2077348013 cites W2059159853 @default.
- W2077348013 cites W2062203382 @default.
- W2077348013 cites W2062375466 @default.
- W2077348013 cites W2063443054 @default.
- W2077348013 cites W2064688638 @default.
- W2077348013 cites W2064953660 @default.
- W2077348013 cites W2065069478 @default.
- W2077348013 cites W2067039239 @default.
- W2077348013 cites W2074580166 @default.
- W2077348013 cites W2077426593 @default.
- W2077348013 cites W2077549773 @default.
- W2077348013 cites W2080944779 @default.
- W2077348013 cites W2082782176 @default.
- W2077348013 cites W2086037386 @default.
- W2077348013 cites W2091988963 @default.
- W2077348013 cites W2092358916 @default.
- W2077348013 cites W2095897702 @default.
- W2077348013 cites W2106766847 @default.
- W2077348013 cites W2119905134 @default.
- W2077348013 cites W2146048290 @default.
- W2077348013 cites W2148255642 @default.
- W2077348013 cites W2152567653 @default.
- W2077348013 cites W2167341970 @default.
- W2077348013 cites W2169079203 @default.
- W2077348013 cites W2312532289 @default.
- W2077348013 cites W4210979710 @default.
- W2077348013 cites W4211193695 @default.
- W2077348013 cites W4327766731 @default.
- W2077348013 doi "https://doi.org/10.1016/j.brainres.2005.04.073" @default.
- W2077348013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15932749" @default.
- W2077348013 hasPublicationYear "2005" @default.
- W2077348013 type Work @default.
- W2077348013 sameAs 2077348013 @default.
- W2077348013 citedByCount "21" @default.
- W2077348013 countsByYear W20773480132012 @default.
- W2077348013 countsByYear W20773480132013 @default.
- W2077348013 countsByYear W20773480132015 @default.
- W2077348013 countsByYear W20773480132017 @default.
- W2077348013 countsByYear W20773480132023 @default.
- W2077348013 crossrefType "journal-article" @default.
- W2077348013 hasAuthorship W2077348013A5010394291 @default.
- W2077348013 hasAuthorship W2077348013A5024751759 @default.
- W2077348013 hasAuthorship W2077348013A5032600833 @default.
- W2077348013 hasAuthorship W2077348013A5046543918 @default.
- W2077348013 hasAuthorship W2077348013A5062324929 @default.
- W2077348013 hasAuthorship W2077348013A5065046382 @default.
- W2077348013 hasAuthorship W2077348013A5082255640 @default.
- W2077348013 hasConcept C134018914 @default.
- W2077348013 hasConcept C150903083 @default.
- W2077348013 hasConcept C153461711 @default.
- W2077348013 hasConcept C170493617 @default.
- W2077348013 hasConcept C178790620 @default.
- W2077348013 hasConcept C185592680 @default.
- W2077348013 hasConcept C202751555 @default.