FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077355854> ?p ?o ?g. }

• W2077355854 endingPage "607" @default.
• W2077355854 startingPage "601" @default.
• W2077355854 abstract "Lead is an environmental toxin and its effects are principally manifested in the brain. Glial and neuronal changes have been described during development following chronic or acute lead intoxication, however, little is known about the effects of chronic lead intoxication in adults. In this study we evaluated immunohistochemically the glial and dopaminergic systems in adult male Wistar rats. 0.5% (v/v) lead acetate in drinking water was administrated chronically over a 3-month period. Hypertrophic immunoreactive astrocytes were observed in the frontal cortex and other brain structures of the treated animals. Analysis of the astroglial features showed increased number of astrocyte cell bodies and processes in treated rats, an increase confirmed by Western blot. Particular distribution of glial fibrillary acidic protein immunoreactivity was observed within the blood vessel walls in which dense immunoreactive glial processes emanate from astrocytes. Glial changes in the frontal cortex were concomitant with reduced tyrosine hydroxylase immunoreactive neuronal processes, which seem to occur as a consequence of significantly reduced dopaminergic neurons within the nucleus of origin in the substantia nigra. These glial and neuronal changes following lead intoxication may affect animal behavior as evidenced by reduced locomotor activity in an open field test. These findings demonstrate that chronic lead exposure induces astroglial changes, which may compromise neuronal function and consequently animal behavior." @default.
• W2077355854 created "2016-06-24" @default.
• W2077355854 creator A5034982809 @default.
• W2077355854 creator A5067093287 @default.
• W2077355854 creator A5082630029 @default.
• W2077355854 date "2011-10-01" @default.
• W2077355854 modified "2023-09-26" @default.
• W2077355854 title "Chronic lead intoxication affects glial and neural systems and induces hypoactivity in adult rat" @default.
• W2077355854 cites W1493812048 @default.
• W2077355854 cites W1963488308 @default.
• W2077355854 cites W1966167674 @default.
• W2077355854 cites W1967485331 @default.
• W2077355854 cites W1992231858 @default.
• W2077355854 cites W1997619705 @default.
• W2077355854 cites W2004858797 @default.
• W2077355854 cites W2017611344 @default.
• W2077355854 cites W2018458500 @default.
• W2077355854 cites W2019625143 @default.
• W2077355854 cites W2023484584 @default.
• W2077355854 cites W2025503832 @default.
• W2077355854 cites W2027235829 @default.
• W2077355854 cites W2029856419 @default.
• W2077355854 cites W2034738430 @default.
• W2077355854 cites W2039004863 @default.
• W2077355854 cites W2040890547 @default.
• W2077355854 cites W2044730840 @default.
• W2077355854 cites W2045394310 @default.
• W2077355854 cites W2045421013 @default.
• W2077355854 cites W2045871851 @default.
• W2077355854 cites W2047390168 @default.
• W2077355854 cites W2051094052 @default.
• W2077355854 cites W2054509174 @default.
• W2077355854 cites W2056097881 @default.
• W2077355854 cites W2057386472 @default.
• W2077355854 cites W2061687910 @default.
• W2077355854 cites W2070757600 @default.
• W2077355854 cites W2073633014 @default.
• W2077355854 cites W2076313617 @default.
• W2077355854 cites W2081915484 @default.
• W2077355854 cites W2083193334 @default.
• W2077355854 cites W2093090474 @default.
• W2077355854 cites W2094776358 @default.
• W2077355854 cites W2097285094 @default.
• W2077355854 cites W2100625035 @default.
• W2077355854 cites W2118522143 @default.
• W2077355854 cites W2129212626 @default.
• W2077355854 cites W2139155172 @default.
• W2077355854 cites W2142133036 @default.
• W2077355854 cites W2142448948 @default.
• W2077355854 cites W2143240446 @default.
• W2077355854 cites W2144159121 @default.
• W2077355854 cites W2144642885 @default.
• W2077355854 cites W2146334297 @default.
• W2077355854 cites W2167921058 @default.
• W2077355854 doi "https://doi.org/10.1016/j.acthis.2010.06.005" @default.
• W2077355854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20656334" @default.
• W2077355854 hasPublicationYear "2011" @default.
• W2077355854 type Work @default.
• W2077355854 sameAs 2077355854 @default.
• W2077355854 citedByCount "55" @default.
• W2077355854 countsByYear W20773558542012 @default.
• W2077355854 countsByYear W20773558542013 @default.
• W2077355854 countsByYear W20773558542014 @default.
• W2077355854 countsByYear W20773558542015 @default.
• W2077355854 countsByYear W20773558542016 @default.
• W2077355854 countsByYear W20773558542017 @default.
• W2077355854 countsByYear W20773558542018 @default.
• W2077355854 countsByYear W20773558542019 @default.
• W2077355854 countsByYear W20773558542021 @default.
• W2077355854 countsByYear W20773558542022 @default.
• W2077355854 countsByYear W20773558542023 @default.
• W2077355854 crossrefType "journal-article" @default.
• W2077355854 hasAuthorship W2077355854A5034982809 @default.
• W2077355854 hasAuthorship W2077355854A5067093287 @default.
• W2077355854 hasAuthorship W2077355854A5082630029 @default.
• W2077355854 hasConcept C126322002 @default.
• W2077355854 hasConcept C134018914 @default.
• W2077355854 hasConcept C137183658 @default.
• W2077355854 hasConcept C159167319 @default.
• W2077355854 hasConcept C169760540 @default.
• W2077355854 hasConcept C204232928 @default.
• W2077355854 hasConcept C2777542381 @default.
• W2077355854 hasConcept C2779224224 @default.
• W2077355854 hasConcept C2779424989 @default.
• W2077355854 hasConcept C2779965356 @default.
• W2077355854 hasConcept C2780495277 @default.
• W2077355854 hasConcept C2780884517 @default.
• W2077355854 hasConcept C2780938664 @default.
• W2077355854 hasConcept C29730261 @default.
• W2077355854 hasConcept C513476851 @default.
• W2077355854 hasConcept C529278444 @default.
• W2077355854 hasConcept C71924100 @default.
• W2077355854 hasConcept C86803240 @default.
• W2077355854 hasConceptScore W2077355854C126322002 @default.
• W2077355854 hasConceptScore W2077355854C134018914 @default.
• W2077355854 hasConceptScore W2077355854C137183658 @default.
• W2077355854 hasConceptScore W2077355854C159167319 @default.
• W2077355854 hasConceptScore W2077355854C169760540 @default.

• next