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- W2077358051 abstract "Soft tissue sarcomas are rare, with some 1200 new cases in the UK each year; clinicians outside specialist centres see no more than a few. They involve principally the soft connective tissues of the limbs, limb girdles and retroperitoneum, and also occur in the head and neck, and abdominal and chest walls. There are now some 50 recognizable histological subtypes [1], but there is generally a uniform clinicopathological approach since sarcomas present common clinical problems, arising out of their natural history. These involve management of primary turnouts by surgery (with or without preoperative irradiation), local control of recurrent disease (principally by surgery and radiotherapy), and the treatment of metastases, usually in the lungs but sometimes in regional lymph nodes (which are particularly likely to be involved by rhabdomyosarcoma, and synovial, epithelioid or clear cell sarcomas). For disseminated disease it is true that, apart from some childhood tumours, specific or effective chemotherapy is not yet available, although pulmonary metastasectomy may have a place. However, in recent years, careful clinicopathological observations, newer histological techniques, and contributions from cytogenetics have delineated the incidences and natural histories of a number of new entities and questioned our concepts of some established tumour types. These advances are valuable in epidemiology, and for better defining subtypes for multicentre therapeutic trials. Most importantly, because many sarcoma subtypes behave in a reasonably consistent fashion, sensible predictions of the potential and likely time course for recurrence and metastasis become possible in individual tumours. Thus, the necessary initial step in management of a soft tissue sarcoma is to make a definite and accurate histological diagnosis." @default.
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- W2077358051 date "1992-01-01" @default.
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- W2077358051 title "Soft tissue sarcomas" @default.
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- W2077358051 doi "https://doi.org/10.1016/s0936-6555(05)81108-2" @default.
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