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• W2077361707 abstract "In the rabbit, either coitus or intraventricular administration of norepinephrine (NE) induces gonadotropin release and ovulation. It is hypothesized that ovulation induced with these manipulations involves activation of neuronal pathways that include catecholaminergic and peptidergic neurons. The aim of this study was to examine if perfusion of NE directly through the mediobasal hypothalamus (MBH) stimulates gonadotropin-releasing hormone (GnRH) release from the MBH in ovariectomized (OVEX) and estradiol-treated OVEX does (OVEX/E2). All does were fitted with push-pull (PP) cannulae directed to the MBH and subsequently subjected to PP perfusion at a flow rate of 20 μl/min for 6 h to measure hypothalamic GnRH release. Five OVEX/E2 and 7 OVEX does received NE that was added to the PP system (intrahypothalamic NE perfusion) at the rate of 2.5 μg/min for 2 h during 6 h of PP perfusion. In addition, 6 OVEX/E2 does were given intrahypothalamic perfusion of homovanillic acid (HVA), a metabolite of the adrenergic system, to serve as controls. All PP samples were collected on ice at 10-min intervals, and jugular vein blood samples were obtained at 20-min intervals. The GnRH, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured by specific radioimmunoassays. In OVEX/E2 does, intrahypothalamic perfusion of NE, but not HVA, stimulated a 10-fold increase in peak values of hypothalamic GnRH within 30 min, and a 3-fold increase in peak values of plasma LH within 40 min. Thereafter, both GnRH and LH levels returned to basal values by the end of the NE perfusion. In contrast, the same NE treatment failed to stimulate GnRH and LH release in OVEX does. Changes in plasma FSH after NE were not observed in any of the 3 groups of animals. These results demonstrate that the NE-stimulated neuronal discharge of GnRH, that is accompanied by an increase in plasma LH, is estrogen dependent. The results further support the hypothesis that GnRH is the final common pathway that mediates the effect of brain NE on pituitary gonadotropes." @default.
• W2077361707 created "2016-06-24" @default.
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• W2077361707 date "1986-12-01" @default.
• W2077361707 modified "2023-10-16" @default.
• W2077361707 title "Estrogen-dependent effects of norepinephrine on hypothalamic gonadotropin-releasing hormone release in the rabbit" @default.
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• W2077361707 doi "https://doi.org/10.1016/0006-8993(86)90596-2" @default.
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