FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077362018> ?p ?o ?g. }

• W2077362018 endingPage "1388" @default.
• W2077362018 startingPage "1378" @default.
• W2077362018 abstract "Previously we have shown that interferon (IFN)-α induced apoptosis is predominantly mediated by the upregulation of tumor necrosis factor related apoptosis-inducing ligand (TRAIL) via the caspase-8 pathway. It was also shown that recruitment of mitochondria in IFN-α induced apoptosis involves the cleavage of BH3 interacting domain death agonist (Bid) to truncated Bid (tBid). In the present study, we demonstrate that tBid induced by IFN-α2a activates mitochondrial Bak to trigger the loss of mitochondrial membrane integrity, consequently causing release of apoptosis-inducing factor (AIF) in ovarian cancer cells, OVCAR3. AIF translocates from the mitochondria to the nucleus and induces nuclear fragmentation and cell death. Both a small molecule Bid inhibitor (BI-6C9) or Bid-RNA interference (RNAi) preserved mitochondrial membrane potential, prevented nuclear translocation of AIF, and abrogated IFN-α2a-induced cell death. Cell death induced by tBid was inhibited by AIF-RNAi, indicating that caspase-independent AIF signaling is the main pathway through which Bid mediates cell death. This was further supported by experiments showing that BI-6C9 did not prevent the release of cytochrome c from mitochondria to cytosol, while the release of AIF was prevented. In conclusion, IFN-α2a-induced apoptosis is mediated via the mitochondria-associated pathway involving the cleavage of Bid followed by AIF release that involves Bak activation and translocation of AIF from the mitochondria to the nucleus in OVCAR3 cells." @default.
• W2077362018 created "2016-06-24" @default.
• W2077362018 creator A5025528747 @default.
• W2077362018 creator A5059575766 @default.
• W2077362018 creator A5062835235 @default.
• W2077362018 creator A5077877614 @default.
• W2077362018 creator A5080821313 @default.
• W2077362018 date "2012-08-01" @default.
• W2077362018 modified "2023-10-18" @default.
• W2077362018 title "Apoptosis-inducing factor (AIF) is targeted in IFN-α2a-induced Bid‐mediated apoptosis through Bak activation in ovarian cancer cells" @default.
• W2077362018 cites W1554372630 @default.
• W2077362018 cites W1607777232 @default.
• W2077362018 cites W1904882776 @default.
• W2077362018 cites W1913661233 @default.
• W2077362018 cites W1964193578 @default.
• W2077362018 cites W1981885332 @default.
• W2077362018 cites W1983089176 @default.
• W2077362018 cites W1984547206 @default.
• W2077362018 cites W1988777405 @default.
• W2077362018 cites W1993300108 @default.
• W2077362018 cites W1999610462 @default.
• W2077362018 cites W2012805235 @default.
• W2077362018 cites W2015544673 @default.
• W2077362018 cites W2033774856 @default.
• W2077362018 cites W2039191003 @default.
• W2077362018 cites W2052853635 @default.
• W2077362018 cites W2062853648 @default.
• W2077362018 cites W2068146558 @default.
• W2077362018 cites W2075217355 @default.
• W2077362018 cites W2075972578 @default.
• W2077362018 cites W2079367201 @default.
• W2077362018 cites W2085669605 @default.
• W2077362018 cites W2086144679 @default.
• W2077362018 cites W2096012548 @default.
• W2077362018 cites W2099067831 @default.
• W2077362018 cites W2101028231 @default.
• W2077362018 cites W2103565638 @default.
• W2077362018 cites W2145356695 @default.
• W2077362018 cites W2153398168 @default.
• W2077362018 cites W2154346380 @default.
• W2077362018 cites W2155326190 @default.
• W2077362018 cites W2156397833 @default.
• W2077362018 cites W2159650080 @default.
• W2077362018 cites W2161135907 @default.
• W2077362018 cites W2161832141 @default.
• W2077362018 cites W2162441925 @default.
• W2077362018 cites W2177943720 @default.
• W2077362018 cites W2316016553 @default.
• W2077362018 cites W2019851785 @default.
• W2077362018 doi "https://doi.org/10.1016/j.bbamcr.2012.05.031" @default.
• W2077362018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3389262" @default.
• W2077362018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22683989" @default.
• W2077362018 hasPublicationYear "2012" @default.
• W2077362018 type Work @default.
• W2077362018 sameAs 2077362018 @default.
• W2077362018 citedByCount "21" @default.
• W2077362018 countsByYear W20773620182013 @default.
• W2077362018 countsByYear W20773620182014 @default.
• W2077362018 countsByYear W20773620182015 @default.
• W2077362018 countsByYear W20773620182016 @default.
• W2077362018 countsByYear W20773620182018 @default.
• W2077362018 countsByYear W20773620182019 @default.
• W2077362018 countsByYear W20773620182020 @default.
• W2077362018 countsByYear W20773620182022 @default.
• W2077362018 countsByYear W20773620182023 @default.
• W2077362018 crossrefType "journal-article" @default.
• W2077362018 hasAuthorship W2077362018A5025528747 @default.
• W2077362018 hasAuthorship W2077362018A5059575766 @default.
• W2077362018 hasAuthorship W2077362018A5062835235 @default.
• W2077362018 hasAuthorship W2077362018A5077877614 @default.
• W2077362018 hasAuthorship W2077362018A5080821313 @default.
• W2077362018 hasBestOaLocation W20773620181 @default.
• W2077362018 hasConcept C172043667 @default.
• W2077362018 hasConcept C185592680 @default.
• W2077362018 hasConcept C190283241 @default.
• W2077362018 hasConcept C28859421 @default.
• W2077362018 hasConcept C31573885 @default.
• W2077362018 hasConcept C502942594 @default.
• W2077362018 hasConcept C55493867 @default.
• W2077362018 hasConcept C56483683 @default.
• W2077362018 hasConcept C62478195 @default.
• W2077362018 hasConcept C86803240 @default.
• W2077362018 hasConcept C95444343 @default.
• W2077362018 hasConcept C98424977 @default.
• W2077362018 hasConceptScore W2077362018C172043667 @default.
• W2077362018 hasConceptScore W2077362018C185592680 @default.
• W2077362018 hasConceptScore W2077362018C190283241 @default.
• W2077362018 hasConceptScore W2077362018C28859421 @default.
• W2077362018 hasConceptScore W2077362018C31573885 @default.
• W2077362018 hasConceptScore W2077362018C502942594 @default.
• W2077362018 hasConceptScore W2077362018C55493867 @default.
• W2077362018 hasConceptScore W2077362018C56483683 @default.
• W2077362018 hasConceptScore W2077362018C62478195 @default.
• W2077362018 hasConceptScore W2077362018C86803240 @default.
• W2077362018 hasConceptScore W2077362018C95444343 @default.
• W2077362018 hasConceptScore W2077362018C98424977 @default.
• W2077362018 hasIssue "8" @default.
• W2077362018 hasLocation W20773620181 @default.

• next