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- W2077365247 abstract "The in vitro and in vivo antineoplastic activity of 5-AZA-2'-deoxycytidine (5-AZA-CdR) and β-2-deoxythioguanosine (TGdR) on L1210 an L1210/ARA-C (resistant to cytosine arabinoside) leukemic cells was investigated. 5-AZA-CdR was a very potent cytotoxic agent against the L1210 leukemic cells. This analogue was inactive against L1210/ARA-C leukemic cells because these cells lack deoxycytidine kinase, the enzyme that converts 5-AZA-CdR to its active nucleotide form. TGdR was a potent cytotoxic agent to both L1210 and L1210/ARA-C leukemic cells. In mice which were injected simultaneously with both L1210 and L1210/ARA-C leukemic cells, the drug combination of 5-AZA-CdR plus TGdR had a very potent antineoplastic activity and producet long-term survivors. Either agent alone did not produce any long-term survivors in the mice with L1210 and L1210/ARA-C leukemia. This experimental model indicates that 5-AZA-CdR plus TGdR is an interesting drug combination for the treatment of leukemia with drug-resistant cells." @default.
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- W2077365247 date "1982-09-15" @default.
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- W2077365247 title "Combinational chemotherapy of L1210 and L1210/ARA-C leukemia with 5-AZA-2′-deoxycytidine and β-2′-deoxythioguanosine" @default.
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- W2077365247 doi "https://doi.org/10.1002/ijc.2910300317" @default.
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