Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077370216> ?p ?o ?g. }
- W2077370216 endingPage "441" @default.
- W2077370216 startingPage "434" @default.
- W2077370216 abstract "Parafibromin, encoded by HRPT2, is the first marker with significant benefit in the diagnosis of parathyroid carcinoma. However, because parafibromin is only involved in up to 70% of parathyroid carcinomas and loss of parafibromin immunoreactivity may not be observed in all cases of HRPT2 mutation, a complementary marker is needed.We sought to determine the efficacy of increased expression of protein gene product 9.5 (PGP9.5), encoded by ubiquitin carboxyl-terminal esterase L1 (UCHL1) as an additional marker to loss of parafibromin immunoreactivity for the diagnosis of parathyroid carcinoma.In total, 146 parathyroid tumors and nine normal tissues were analyzed for the expression of parafibromin and PGP9.5 by immunohistochemistry and for UCHL1 by quantitative RT-PCR. These samples included six hyperparathyroidism-jaw tumor syndrome-related tumors and 24 sporadic carcinomas.In tumors with evidence of malignancy, strong staining for PGP9.5 had a sensitivity of 78% for the detection of parathyroid carcinoma and/or HRPT2 mutation and a specificity of 100%. Complete lack of nuclear parafibromin staining had a sensitivity of 67% and a specificity of 100%. PGP9.5 was positive in a tumor with the HRPT2 mutation L64P that expressed parafibromin. Furthermore, UCHL1 was highly expressed in the carcinoma/hyperparathyroidism-jaw tumor syndrome group compared to normal (P < 0.05) and benign specimens (P < 0.001).These results suggest that positive staining for PGP9.5 has utility as a marker for parathyroid malignancy, with a slightly superior sensitivity (P = 0.03) and similar high specificity to that of parafibromin." @default.
- W2077370216 created "2016-06-24" @default.
- W2077370216 creator A5001969400 @default.
- W2077370216 creator A5015490244 @default.
- W2077370216 creator A5018860994 @default.
- W2077370216 creator A5032567530 @default.
- W2077370216 creator A5037367588 @default.
- W2077370216 creator A5041064321 @default.
- W2077370216 creator A5048249385 @default.
- W2077370216 creator A5048743050 @default.
- W2077370216 creator A5051055093 @default.
- W2077370216 creator A5076351536 @default.
- W2077370216 date "2009-02-01" @default.
- W2077370216 modified "2023-09-27" @default.
- W2077370216 title "Accuracy of Combined Protein Gene Product 9.5 and Parafibromin Markers for Immunohistochemical Diagnosis of Parathyroid Carcinoma" @default.
- W2077370216 cites W1965768671 @default.
- W2077370216 cites W1966822954 @default.
- W2077370216 cites W1976884107 @default.
- W2077370216 cites W1976928374 @default.
- W2077370216 cites W2030616951 @default.
- W2077370216 cites W2036202821 @default.
- W2077370216 cites W2038954852 @default.
- W2077370216 cites W2043829537 @default.
- W2077370216 cites W2045317384 @default.
- W2077370216 cites W2046619657 @default.
- W2077370216 cites W2051336039 @default.
- W2077370216 cites W2053876525 @default.
- W2077370216 cites W2069912171 @default.
- W2077370216 cites W2096540089 @default.
- W2077370216 cites W2098580959 @default.
- W2077370216 cites W2099249565 @default.
- W2077370216 cites W2100815977 @default.
- W2077370216 cites W2108828245 @default.
- W2077370216 cites W2115054276 @default.
- W2077370216 cites W2117513049 @default.
- W2077370216 cites W2127525778 @default.
- W2077370216 cites W2127537958 @default.
- W2077370216 cites W2130935241 @default.
- W2077370216 cites W2139234044 @default.
- W2077370216 cites W2147037681 @default.
- W2077370216 cites W2150468893 @default.
- W2077370216 cites W2151507328 @default.
- W2077370216 cites W2152117476 @default.
- W2077370216 cites W2158942386 @default.
- W2077370216 cites W2163571202 @default.
- W2077370216 cites W2163705256 @default.
- W2077370216 doi "https://doi.org/10.1210/jc.2008-1740" @default.
- W2077370216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19017757" @default.
- W2077370216 hasPublicationYear "2009" @default.
- W2077370216 type Work @default.
- W2077370216 sameAs 2077370216 @default.
- W2077370216 citedByCount "114" @default.
- W2077370216 countsByYear W20773702162012 @default.
- W2077370216 countsByYear W20773702162013 @default.
- W2077370216 countsByYear W20773702162014 @default.
- W2077370216 countsByYear W20773702162015 @default.
- W2077370216 countsByYear W20773702162016 @default.
- W2077370216 countsByYear W20773702162017 @default.
- W2077370216 countsByYear W20773702162018 @default.
- W2077370216 countsByYear W20773702162019 @default.
- W2077370216 countsByYear W20773702162020 @default.
- W2077370216 countsByYear W20773702162021 @default.
- W2077370216 countsByYear W20773702162022 @default.
- W2077370216 countsByYear W20773702162023 @default.
- W2077370216 crossrefType "journal-article" @default.
- W2077370216 hasAuthorship W2077370216A5001969400 @default.
- W2077370216 hasAuthorship W2077370216A5015490244 @default.
- W2077370216 hasAuthorship W2077370216A5018860994 @default.
- W2077370216 hasAuthorship W2077370216A5032567530 @default.
- W2077370216 hasAuthorship W2077370216A5037367588 @default.
- W2077370216 hasAuthorship W2077370216A5041064321 @default.
- W2077370216 hasAuthorship W2077370216A5048249385 @default.
- W2077370216 hasAuthorship W2077370216A5048743050 @default.
- W2077370216 hasAuthorship W2077370216A5051055093 @default.
- W2077370216 hasAuthorship W2077370216A5076351536 @default.
- W2077370216 hasBestOaLocation W20773702161 @default.
- W2077370216 hasConcept C121608353 @default.
- W2077370216 hasConcept C126322002 @default.
- W2077370216 hasConcept C134018914 @default.
- W2077370216 hasConcept C142724271 @default.
- W2077370216 hasConcept C204232928 @default.
- W2077370216 hasConcept C2777546739 @default.
- W2077370216 hasConcept C2777919317 @default.
- W2077370216 hasConcept C2779053571 @default.
- W2077370216 hasConcept C2779399171 @default.
- W2077370216 hasConcept C2781447364 @default.
- W2077370216 hasConcept C71924100 @default.
- W2077370216 hasConcept C86803240 @default.
- W2077370216 hasConceptScore W2077370216C121608353 @default.
- W2077370216 hasConceptScore W2077370216C126322002 @default.
- W2077370216 hasConceptScore W2077370216C134018914 @default.
- W2077370216 hasConceptScore W2077370216C142724271 @default.
- W2077370216 hasConceptScore W2077370216C204232928 @default.
- W2077370216 hasConceptScore W2077370216C2777546739 @default.
- W2077370216 hasConceptScore W2077370216C2777919317 @default.
- W2077370216 hasConceptScore W2077370216C2779053571 @default.
- W2077370216 hasConceptScore W2077370216C2779399171 @default.
- W2077370216 hasConceptScore W2077370216C2781447364 @default.