FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077377112> ?p ?o ?g. }

• W2077377112 endingPage "46" @default.
• W2077377112 startingPage "41" @default.
• W2077377112 abstract "Langerhans' cell histiocytosis (LCH) is a neoplastic disease due to uncontrolled proliferation of Langerhans' cells (LCs); damage to organs involved appears to be due to the various cytokines secreted. The true cause of LCH remains a mystery. LCH can present at any age; there is female predominance and the skin is often the first site to be involved. Scaly papules, vesicles, purpuric nodules, plaques and ulcers are the main diverse presentations typically found on the scalp, flexures (including the perineum), crease below the breast, palms, soles and nails. The patient described here is a 35-year-old Saudi Arabian woman with a vulval ulcer that had been misdiagnosed as an infective lesion 11 months before the correct diagnosis of LCH was made by means of biopsy examination. Diffuse infiltration of LCs with large pale reniform/convoluted nuclei and abundant amphophilic cytoplasm in the company of neutrophils, eosinophils, lymphocytes and plasma cells were observed on light microscopy. Immunohistochemical staining, indicating S100 protein positivity in LCs and the demonstration of Birbeck granules by means of electron microscopy, confirmed the diagnosis. The 'skin-only' LCH may later progress to involve other organs; alternatively skin lesions may be part of the multisystem, disseminated disease. There is need for careful follow-up of all LCH patients, as the course of the disease cannot be reliably predicted from either the clinical presentation or histology of the lesion. In many cases the prognosis is good, there being limited involvement that does not progress. Surgery or local steroids might suffice as therapy. However, for severely symptomatic disease, in which there are complications associated with dysfunction (or failure) of vital organs such as the liver, lungs, and central nervous system, the use of a variety of immunosuppressive treatments--and the recently described 2-chloro-2-deoxyadenosine (2CdA) (cladribine)--have been suggested; however, the type and extent of disease that will respond to this therapy has not yet been clarified. Solid laboratory research and rigorous clinical trials are required for more effective and less toxic therapies for patients with progressive LCH." @default.
• W2077377112 created "2016-06-24" @default.
• W2077377112 creator A5012388216 @default.
• W2077377112 creator A5027624235 @default.
• W2077377112 creator A5078976249 @default.
• W2077377112 date "2008-01-01" @default.
• W2077377112 modified "2023-09-27" @default.
• W2077377112 title "Lessons to be learned — Langerhans' cell histiocytosis" @default.
• W2077377112 cites W1500636739 @default.
• W2077377112 cites W160435835 @default.
• W2077377112 cites W1971261709 @default.
• W2077377112 cites W1980255149 @default.
• W2077377112 cites W2012690047 @default.
• W2077377112 cites W2013204677 @default.
• W2077377112 cites W2014794833 @default.
• W2077377112 cites W2029082634 @default.
• W2077377112 cites W2031368093 @default.
• W2077377112 cites W2036968156 @default.
• W2077377112 cites W2042736506 @default.
• W2077377112 cites W2053095538 @default.
• W2077377112 cites W2057487447 @default.
• W2077377112 cites W2063229820 @default.
• W2077377112 cites W2063907935 @default.
• W2077377112 cites W2064662665 @default.
• W2077377112 cites W2067866425 @default.
• W2077377112 cites W2073864150 @default.
• W2077377112 cites W2079532289 @default.
• W2077377112 cites W2084771620 @default.
• W2077377112 cites W2088694943 @default.
• W2077377112 cites W2091364998 @default.
• W2077377112 cites W2107277144 @default.
• W2077377112 cites W2154463442 @default.
• W2077377112 cites W2325716909 @default.
• W2077377112 cites W2614123547 @default.
• W2077377112 cites W31990271 @default.
• W2077377112 doi "https://doi.org/10.1177/1466424007085224" @default.
• W2077377112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18274329" @default.
• W2077377112 hasPublicationYear "2008" @default.
• W2077377112 type Work @default.
• W2077377112 sameAs 2077377112 @default.
• W2077377112 citedByCount "5" @default.
• W2077377112 countsByYear W20773771122014 @default.
• W2077377112 countsByYear W20773771122016 @default.
• W2077377112 countsByYear W20773771122019 @default.
• W2077377112 countsByYear W20773771122020 @default.
• W2077377112 crossrefType "journal-article" @default.
• W2077377112 hasAuthorship W2077377112A5012388216 @default.
• W2077377112 hasAuthorship W2077377112A5027624235 @default.
• W2077377112 hasAuthorship W2077377112A5078976249 @default.
• W2077377112 hasConcept C121332964 @default.
• W2077377112 hasConcept C142724271 @default.
• W2077377112 hasConcept C147483822 @default.
• W2077377112 hasConcept C153400128 @default.
• W2077377112 hasConcept C203014093 @default.
• W2077377112 hasConcept C204232928 @default.
• W2077377112 hasConcept C2775934546 @default.
• W2077377112 hasConcept C2777484599 @default.
• W2077377112 hasConcept C2778379841 @default.
• W2077377112 hasConcept C2778833550 @default.
• W2077377112 hasConcept C2779134260 @default.
• W2077377112 hasConcept C2780174970 @default.
• W2077377112 hasConcept C2780439664 @default.
• W2077377112 hasConcept C2780851604 @default.
• W2077377112 hasConcept C2781156865 @default.
• W2077377112 hasConcept C71924100 @default.
• W2077377112 hasConcept C97355855 @default.
• W2077377112 hasConceptScore W2077377112C121332964 @default.
• W2077377112 hasConceptScore W2077377112C142724271 @default.
• W2077377112 hasConceptScore W2077377112C147483822 @default.
• W2077377112 hasConceptScore W2077377112C153400128 @default.
• W2077377112 hasConceptScore W2077377112C203014093 @default.
• W2077377112 hasConceptScore W2077377112C204232928 @default.
• W2077377112 hasConceptScore W2077377112C2775934546 @default.
• W2077377112 hasConceptScore W2077377112C2777484599 @default.
• W2077377112 hasConceptScore W2077377112C2778379841 @default.
• W2077377112 hasConceptScore W2077377112C2778833550 @default.
• W2077377112 hasConceptScore W2077377112C2779134260 @default.
• W2077377112 hasConceptScore W2077377112C2780174970 @default.
• W2077377112 hasConceptScore W2077377112C2780439664 @default.
• W2077377112 hasConceptScore W2077377112C2780851604 @default.
• W2077377112 hasConceptScore W2077377112C2781156865 @default.
• W2077377112 hasConceptScore W2077377112C71924100 @default.
• W2077377112 hasConceptScore W2077377112C97355855 @default.
• W2077377112 hasIssue "1" @default.
• W2077377112 hasLocation W20773771121 @default.
• W2077377112 hasLocation W20773771122 @default.
• W2077377112 hasOpenAccess W2077377112 @default.
• W2077377112 hasPrimaryLocation W20773771121 @default.
• W2077377112 hasRelatedWork W1963041435 @default.
• W2077377112 hasRelatedWork W2003494977 @default.
• W2077377112 hasRelatedWork W2004123073 @default.
• W2077377112 hasRelatedWork W2009657118 @default.
• W2077377112 hasRelatedWork W2029280381 @default.
• W2077377112 hasRelatedWork W2124576913 @default.
• W2077377112 hasRelatedWork W2158105297 @default.
• W2077377112 hasRelatedWork W2171896760 @default.
• W2077377112 hasRelatedWork W2432652607 @default.
• W2077377112 hasRelatedWork W2462823902 @default.

• next