Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077377556> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2077377556 endingPage "255" @default.
- W2077377556 startingPage "251" @default.
- W2077377556 abstract "Therapy with fresh frozen plasma (FFP) confers serious risks, such as contraction of blood-borne viruses, allergic reaction, volume overload and development of alloantibodies. The aim of this study was to apply principles of pharmacokinetic (PK) modelling to individual factor content of FFP to optimize individualized dosing, while minimizing potential risks of therapy. We used PK modelling to successfully target individual factor replacement in an 8-month-old patient receiving FFP for treatment of a severe congenital factor V (FV) deficiency. The model fit for the FV activity vs. time data was excellent (r = 0.98) and the model accurately predicted FV activity during the intraoperative and postoperative period. Accurate PK modelling of individual factor activity in FFP has the potential to provide better targeted therapy, enabling clinicians to more precisely dose patients requiring coagulation products, while avoiding wasteful and expensive product overtreatment, minimizing potentially life-threatening complications due to undertreatment and limiting harmful product-associated risks." @default.
- W2077377556 created "2016-06-24" @default.
- W2077377556 creator A5055952263 @default.
- W2077377556 creator A5073134373 @default.
- W2077377556 creator A5075862876 @default.
- W2077377556 creator A5079984890 @default.
- W2077377556 creator A5090177046 @default.
- W2077377556 date "2012-11-23" @default.
- W2077377556 modified "2023-09-23" @default.
- W2077377556 title "Use of pharmacokinetic modelling to individualize FFP dosing in factor V deficiency" @default.
- W2077377556 cites W1529715073 @default.
- W2077377556 cites W1569602075 @default.
- W2077377556 cites W1598075387 @default.
- W2077377556 cites W1836963087 @default.
- W2077377556 cites W1964148546 @default.
- W2077377556 cites W1978184135 @default.
- W2077377556 cites W1986601719 @default.
- W2077377556 cites W2020547352 @default.
- W2077377556 cites W2043573822 @default.
- W2077377556 cites W2045886098 @default.
- W2077377556 cites W2051992796 @default.
- W2077377556 cites W2063833780 @default.
- W2077377556 cites W2082554533 @default.
- W2077377556 cites W2085130102 @default.
- W2077377556 cites W2089678929 @default.
- W2077377556 cites W2092087640 @default.
- W2077377556 cites W2118538805 @default.
- W2077377556 cites W2126147481 @default.
- W2077377556 cites W2135468468 @default.
- W2077377556 cites W2396013837 @default.
- W2077377556 doi "https://doi.org/10.1111/hae.12045" @default.
- W2077377556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7704113" @default.
- W2077377556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23173558" @default.
- W2077377556 hasPublicationYear "2012" @default.
- W2077377556 type Work @default.
- W2077377556 sameAs 2077377556 @default.
- W2077377556 citedByCount "5" @default.
- W2077377556 countsByYear W20773775562014 @default.
- W2077377556 countsByYear W20773775562017 @default.
- W2077377556 countsByYear W20773775562018 @default.
- W2077377556 countsByYear W20773775562020 @default.
- W2077377556 crossrefType "journal-article" @default.
- W2077377556 hasAuthorship W2077377556A5055952263 @default.
- W2077377556 hasAuthorship W2077377556A5073134373 @default.
- W2077377556 hasAuthorship W2077377556A5075862876 @default.
- W2077377556 hasAuthorship W2077377556A5079984890 @default.
- W2077377556 hasAuthorship W2077377556A5090177046 @default.
- W2077377556 hasBestOaLocation W20773775562 @default.
- W2077377556 hasConcept C112705442 @default.
- W2077377556 hasConcept C126322002 @default.
- W2077377556 hasConcept C127413603 @default.
- W2077377556 hasConcept C141071460 @default.
- W2077377556 hasConcept C177713679 @default.
- W2077377556 hasConcept C188198153 @default.
- W2077377556 hasConcept C2777288759 @default.
- W2077377556 hasConcept C2777396833 @default.
- W2077377556 hasConcept C2778382381 @default.
- W2077377556 hasConcept C66112548 @default.
- W2077377556 hasConcept C71924100 @default.
- W2077377556 hasConcept C78519656 @default.
- W2077377556 hasConcept C89560881 @default.
- W2077377556 hasConcept C98274493 @default.
- W2077377556 hasConceptScore W2077377556C112705442 @default.
- W2077377556 hasConceptScore W2077377556C126322002 @default.
- W2077377556 hasConceptScore W2077377556C127413603 @default.
- W2077377556 hasConceptScore W2077377556C141071460 @default.
- W2077377556 hasConceptScore W2077377556C177713679 @default.
- W2077377556 hasConceptScore W2077377556C188198153 @default.
- W2077377556 hasConceptScore W2077377556C2777288759 @default.
- W2077377556 hasConceptScore W2077377556C2777396833 @default.
- W2077377556 hasConceptScore W2077377556C2778382381 @default.
- W2077377556 hasConceptScore W2077377556C66112548 @default.
- W2077377556 hasConceptScore W2077377556C71924100 @default.
- W2077377556 hasConceptScore W2077377556C78519656 @default.
- W2077377556 hasConceptScore W2077377556C89560881 @default.
- W2077377556 hasConceptScore W2077377556C98274493 @default.
- W2077377556 hasIssue "2" @default.
- W2077377556 hasLocation W20773775561 @default.
- W2077377556 hasLocation W20773775562 @default.
- W2077377556 hasLocation W20773775563 @default.
- W2077377556 hasOpenAccess W2077377556 @default.
- W2077377556 hasPrimaryLocation W20773775561 @default.
- W2077377556 hasRelatedWork W1566760294 @default.
- W2077377556 hasRelatedWork W1861396147 @default.
- W2077377556 hasRelatedWork W1974357355 @default.
- W2077377556 hasRelatedWork W1978184135 @default.
- W2077377556 hasRelatedWork W2026851381 @default.
- W2077377556 hasRelatedWork W2077377556 @default.
- W2077377556 hasRelatedWork W2139801997 @default.
- W2077377556 hasRelatedWork W2308266606 @default.
- W2077377556 hasRelatedWork W2789736893 @default.
- W2077377556 hasRelatedWork W3103251031 @default.
- W2077377556 hasVolume "19" @default.
- W2077377556 isParatext "false" @default.
- W2077377556 isRetracted "false" @default.
- W2077377556 magId "2077377556" @default.
- W2077377556 workType "article" @default.