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• W2077378384 abstract "OBJECTIVE: The aim of this study was to determine the influence of follicular hormone levels in the quality of the embryos.DESIGN: Prospective randomized study in which we determined the levels of Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), Testosterone (T), Progesterone (P) and Estradiol (E) in follicular microenvironment and their influence in the embryo quality.MATERIALS AND METHODS: We included 58 patients from January to April 2008 underwent IVF treatment. The exclusion criteria were: male factor, endometriosis, polycystic ovary syndrome, over 41 years old, low responder patients and FSH > 12 mUI/ml. We assigned the patients randomly to one of these groups: 25 patients in GnRh agonist group (Procrin, ABBOT); and 33 in GnRh antagonist group (Cetrotide, Serono). We used Gonal-F (Serono) in a step-down protocol, and the antagonist was administered in a multidoses guideline when at least 1 follicle had 14 mm. We recovered the follicular fluids during ovum pick-up and were analyzed by Microparticle Enzyme Inmunoassay (MEIA) technology. Moreover we included the following parameters for the multiple regression (ME): age, days of stimulation and total FSH dose.RESULTS: We analyzed the parameters by means of linear regressions, one by one vs the number of top quality embryos (tqe). We only found significant differences with the intrafollicular FSH (tqe=1.4487+1.3953/FSH; r2=33.65%; p=0.0287). When we analyzed there were another two variables that had influence on this model, age (p=0.0497) and intrafollicular testosterone (p=0.0128) generating a strong explanatory model (ANOVA p=0.0107; r2=51.5%). We analyzed only the antagonist group in the same manner, and found that only existed a significant correlation between intrafollicular FSH and tqe (tqe=0.8472+1.3137/FSH; r2=67.13%; p=0.0011) but putting together in a ME there were significance in all the follicular hormones and in the stimulation days (ANOVA p=0.0090; r2=98.35%). When we analyzed the agonist group, we didn't found any significance in the multiple model, but intrafollicular FSH had a strong correlation again with embryo quality (tqe=5.5403-1.0247∗FSH; r2=34.24%; p=0.0456).CONCLUSIONS: Based on this data it seems that there was an important role of intrafollicular hormone levels to predict the embryo quality. This role was cleverer when analyzed intrafollicular FSH that demonstrated to have a decisive influence in the embryo quality. The higher level of intrafollicular FSH the less amounts of top quality embryos. OBJECTIVE: The aim of this study was to determine the influence of follicular hormone levels in the quality of the embryos. DESIGN: Prospective randomized study in which we determined the levels of Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), Testosterone (T), Progesterone (P) and Estradiol (E) in follicular microenvironment and their influence in the embryo quality. MATERIALS AND METHODS: We included 58 patients from January to April 2008 underwent IVF treatment. The exclusion criteria were: male factor, endometriosis, polycystic ovary syndrome, over 41 years old, low responder patients and FSH > 12 mUI/ml. We assigned the patients randomly to one of these groups: 25 patients in GnRh agonist group (Procrin, ABBOT); and 33 in GnRh antagonist group (Cetrotide, Serono). We used Gonal-F (Serono) in a step-down protocol, and the antagonist was administered in a multidoses guideline when at least 1 follicle had 14 mm. We recovered the follicular fluids during ovum pick-up and were analyzed by Microparticle Enzyme Inmunoassay (MEIA) technology. Moreover we included the following parameters for the multiple regression (ME): age, days of stimulation and total FSH dose. RESULTS: We analyzed the parameters by means of linear regressions, one by one vs the number of top quality embryos (tqe). We only found significant differences with the intrafollicular FSH (tqe=1.4487+1.3953/FSH; r2=33.65%; p=0.0287). When we analyzed there were another two variables that had influence on this model, age (p=0.0497) and intrafollicular testosterone (p=0.0128) generating a strong explanatory model (ANOVA p=0.0107; r2=51.5%). We analyzed only the antagonist group in the same manner, and found that only existed a significant correlation between intrafollicular FSH and tqe (tqe=0.8472+1.3137/FSH; r2=67.13%; p=0.0011) but putting together in a ME there were significance in all the follicular hormones and in the stimulation days (ANOVA p=0.0090; r2=98.35%). When we analyzed the agonist group, we didn't found any significance in the multiple model, but intrafollicular FSH had a strong correlation again with embryo quality (tqe=5.5403-1.0247∗FSH; r2=34.24%; p=0.0456). CONCLUSIONS: Based on this data it seems that there was an important role of intrafollicular hormone levels to predict the embryo quality. This role was cleverer when analyzed intrafollicular FSH that demonstrated to have a decisive influence in the embryo quality. The higher level of intrafollicular FSH the less amounts of top quality embryos." @default.
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• W2077378384 date "2008-09-01" @default.
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• W2077378384 title "Intrafollicular microenvironment as embryo quality predictor" @default.
• W2077378384 doi "https://doi.org/10.1016/j.fertnstert.2008.07.132" @default.
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