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• W2077383429 endingPage "66" @default.
• W2077383429 startingPage "56" @default.
• W2077383429 abstract "A petroleum pitch sample collected in a carbon electrode factory was studied using a series of in vivo assays for genotoxicity and enzymatic induction capability. Rats were treated with the petroleum derivative in three doses: 100, 50, and 10 mg/kg body weight. The treatment produced a rapid excretion of mutagenic substances in the urines of the first 24 hr only in rats treated with high doses (100 and 50 mg/kg). No faecal mutagenic activity was observed. Analyses of urinary thioethers showed that urinary metabolites derived from the compounds present in the pitchsample at the lowest doseadministered (10 mg/kg) were eliminated primarily as cysteine conjugates. The pitch sample was found to be a good inducer of pulmonary and hepatic aryl hydrocarbon hydroxylase, especially after a 50 mg/kg dose. Urinary D-glucaric acid content was always statistically increased in treated animals compared with controls, confirming the enzymatic induction activity. Hepatic glutathione-S-transferase activity increased following treatment with 50 and 10 mg/kg doses." @default.
• W2077383429 created "2016-06-24" @default.
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• W2077383429 date "1990-01-01" @default.
• W2077383429 modified "2023-10-16" @default.
• W2077383429 title "Urine mutagenicity and biochemical parameters as markers of exposure to petroleum pitch using a rat model" @default.
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• W2077383429 doi "https://doi.org/10.1002/em.2850150108" @default.
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