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• W2077388611 abstract "The isochroman A 68930 and the benzazepine SKF 82958 are two full dopamine D1 receptor1 agonists. Responses to these compounds are different in several important aspects. When given to rats in a novel environment, A 68930 caused a dose-dependent (0.019–4.9 mg/kg) suppression of locomotion. SKF 82958 had no such effect at any dose studied (0.051–3.3 mg/kg). In animals habituated to the environment, A 68930 had no effect but SKF 82958 increased locomotor activity. Both A 68930 and SKF 82958 caused a decrease in core temperature at early time points. Both agonists increased c-fos and NGFI-A expression in caudate putamen but only SKF 82958 did so in the accumbens nucleus (at 1.6 mg/kg). Quantitative receptor autoradiography showed that A 68930 is 9–13 times more potent than SKF 82958 at displacing the selective dopamine D1 antagonist [3H]SCH 23390. This difference agrees with the difference observed when the agonists were used to stimulate cAMP formation in cells transfected with the D1 receptor. In contrast, SKF 82958 was 5 times more potent than A 68930 in cells transfected with the D5 receptor. We suggest that the balance between signaling via dopamine D1 and D5 receptors determines the functional effects of agonists at D1/D5 receptors." @default.
• W2077388611 created "2016-06-24" @default.
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• W2077388611 date "2005-11-01" @default.
• W2077388611 modified "2023-10-10" @default.
• W2077388611 title "Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors" @default.
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• W2077388611 doi "https://doi.org/10.1016/j.pbb.2005.09.017" @default.
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