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- W2077390959 abstract "Introduction The purpose of the present study was to detect the presence of BASC-like stem cell-related indicators, such as clara cell secretory protein (CCSP), Octamer-4 (OCT4) and Bmi-1, and evaluate their implications in the prognosis of patients with lung adenocarcinoma. Methods Specimens of 134 cases of lung adenocarcinoma were collected after radical surgery from January 1999 to June 2004. Results One hundred and twenty-six cases showed cells that were positive for CCSP, 99 cases positive for OCT4, 91 cases simultaneous expression of CCSP and OCT4 and 74 cases positive for Bmi-1. Bmi-1 was significantly higher in patients at stage III compared to patients at stages I and II. The pattern of survival curves showed that Bmi-1 was a significant prognostic factor of poor overall survival in lung adenocarcinoma patients (P = 0.0000), and the patients with OCT4+ expression showed a greater increase in mortality than OCT4− patients (P = 0.0103). The results of univariate and multivariate Cox analysis revealed that the pathological stages of tumor node metastases (P = 0.037), OCT4 (P = 0.046) and Bmi-1 expression (P = 0.001) were independent prognostic factors. Conclusions OCT4 and Bmi-1 may be good biomarkers to predict the prognosis of patients with completely resected lung adenocarcinoma. J. Surg. Oncol. 2010;102:856–862. © 2010 Wiley-Liss, Inc." @default.
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- W2077390959 date "2010-09-03" @default.
- W2077390959 modified "2023-10-16" @default.
- W2077390959 title "The expression of stem cell-related indicators as a prognostic factor in human lung adenocarcinoma" @default.
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- W2077390959 doi "https://doi.org/10.1002/jso.21718" @default.
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