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- W2077394960 abstract "THE INTRODUCTION of diethyl stilbestrol by Dodds and coworkers in 1938 (1) II initiated an intensive investigation of synthetic estrogenic substances. A large -1L number of reports dealing with clinical (2-22) and laboratory studies (23-33) of this and related compounds have subsequently appeared. The efficacy of this group of compounds as potent estrogens has been adequately demonstrated, both experimentally and clinically. However, toxic manifestations tending to limit the clinical application of such drugs have been generally noted (27, 34-38). The toxicity of stilbestrol led to the utilization of various derivatives in an effort to retain the estrogenie potency of the drug and eradicate its toxic effects. Of the many esters studied, diethyl stilbestrol dipropionate has yielded the least toxic manifestations, while maintaining the same degree of estrogenic potency (38)." @default.
- W2077394960 created "2016-06-24" @default.
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- W2077394960 date "1940-11-01" @default.
- W2077394960 modified "2023-09-27" @default.
- W2077394960 title "ORAL ADMINISTRATION OF DIETHYL STILBESTROL DIPROPIONATE1" @default.
- W2077394960 doi "https://doi.org/10.1210/endo-27-5-739" @default.
- W2077394960 hasPublicationYear "1940" @default.
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