FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077397079> ?p ?o ?g. }

• W2077397079 endingPage "3075" @default.
• W2077397079 startingPage "3062" @default.
• W2077397079 abstract "ABSTRACT Human cytomegalovirus (HCMV) infects a variety of cell types in humans, resulting in a varied pathogenesis in the immunocompromised host. Endothelial cells (ECs) are considered an important target of HCMV infection that may contribute to viral pathogenesis. Although the viral determinants important for entry into ECs are well defined, the molecular determinants regulating postentry tropism in ECs are not known. We previously identified the UL133-UL138 locus encoded within the clinical strain-specific UL b ′ region of the HCMV genome as important for the latent infection in CD34 + hematopoietic progenitor cells (HPCs). Interestingly, this locus, while dispensable for replication in fibroblasts, was required for efficient replication in ECs infected with the TB40E or fusion-inducing factor X (FIX) HCMV strains. ECs infected with a virus lacking the entire locus ( UL133-UL138 NULL virus) complete the immediate-early and early phases of infection but are defective for infectious progeny virus production. ECs infected with UL133-UL138 NULL virus exhibited striking differences in the organization of intracellular membranes and in the assembly of mature virions relative to ECs infected with wild-type (WT) virus. In UL133-UL138 NULL virus-infected ECs, Golgi stacks were disrupted, and the viral assembly compartment characteristic of HCMV infection failed to form. Further, progeny virions in UL133-UL138 NULL virus-infected ECs inefficiently acquired the virion tegument and secondary envelope. These defects were specific to infection in ECs and not observed in fibroblasts infected with UL133-UL138 NULL virus, suggesting an EC-specific requirement for the UL133-UL138 locus for late stages of replication. To our knowledge, the UL133-UL138 locus represents the first cell-type-dependent, postentry tropism determinant required for viral maturation." @default.
• W2077397079 created "2016-06-24" @default.
• W2077397079 creator A5044743233 @default.
• W2077397079 creator A5065542116 @default.
• W2077397079 creator A5074383185 @default.
• W2077397079 date "2013-03-15" @default.
• W2077397079 modified "2023-09-27" @default.
• W2077397079 title "An Endothelial Cell-Specific Requirement for the <i>UL133-UL138</i> Locus of Human Cytomegalovirus for Efficient Virus Maturation" @default.
• W2077397079 cites W1536684667 @default.
• W2077397079 cites W1539529772 @default.
• W2077397079 cites W1596206099 @default.
• W2077397079 cites W1652505473 @default.
• W2077397079 cites W1731809180 @default.
• W2077397079 cites W1946504624 @default.
• W2077397079 cites W1975248583 @default.
• W2077397079 cites W1980312737 @default.
• W2077397079 cites W1980518192 @default.
• W2077397079 cites W1981892114 @default.
• W2077397079 cites W1982187685 @default.
• W2077397079 cites W1983064582 @default.
• W2077397079 cites W1983990357 @default.
• W2077397079 cites W1984176331 @default.
• W2077397079 cites W1985880387 @default.
• W2077397079 cites W1991308016 @default.
• W2077397079 cites W1993678833 @default.
• W2077397079 cites W1998779041 @default.
• W2077397079 cites W2001585697 @default.
• W2077397079 cites W2009474250 @default.
• W2077397079 cites W2012482638 @default.
• W2077397079 cites W2016841044 @default.
• W2077397079 cites W2017317217 @default.
• W2077397079 cites W2019987740 @default.
• W2077397079 cites W2020212191 @default.
• W2077397079 cites W2021304970 @default.
• W2077397079 cites W2029345949 @default.
• W2077397079 cites W2032660967 @default.
• W2077397079 cites W2032911889 @default.
• W2077397079 cites W2042885383 @default.
• W2077397079 cites W2043892409 @default.
• W2077397079 cites W2045944192 @default.
• W2077397079 cites W2048444754 @default.
• W2077397079 cites W2049711896 @default.
• W2077397079 cites W2052378894 @default.
• W2077397079 cites W2053584325 @default.
• W2077397079 cites W2057131858 @default.
• W2077397079 cites W2060043285 @default.
• W2077397079 cites W2061404129 @default.
• W2077397079 cites W2061757869 @default.
• W2077397079 cites W2065505211 @default.
• W2077397079 cites W2065827134 @default.
• W2077397079 cites W2074360461 @default.
• W2077397079 cites W2075517421 @default.
• W2077397079 cites W2077423100 @default.
• W2077397079 cites W2085235429 @default.
• W2077397079 cites W2085280361 @default.
• W2077397079 cites W2092025037 @default.
• W2077397079 cites W2093603781 @default.
• W2077397079 cites W2096963698 @default.
• W2077397079 cites W2104399354 @default.
• W2077397079 cites W2108583777 @default.
• W2077397079 cites W2111433992 @default.
• W2077397079 cites W2111441577 @default.
• W2077397079 cites W2115516753 @default.
• W2077397079 cites W2118937969 @default.
• W2077397079 cites W2122933800 @default.
• W2077397079 cites W2123124091 @default.
• W2077397079 cites W2124152342 @default.
• W2077397079 cites W2125745829 @default.
• W2077397079 cites W2128159409 @default.
• W2077397079 cites W2128476578 @default.
• W2077397079 cites W2130128083 @default.
• W2077397079 cites W2132275721 @default.
• W2077397079 cites W2133329423 @default.
• W2077397079 cites W2133396499 @default.
• W2077397079 cites W2136465127 @default.
• W2077397079 cites W2140391597 @default.
• W2077397079 cites W2151279610 @default.
• W2077397079 cites W2152460995 @default.
• W2077397079 cites W2154123565 @default.
• W2077397079 cites W2154154520 @default.
• W2077397079 cites W2154539817 @default.
• W2077397079 cites W2160245647 @default.
• W2077397079 cites W2164010581 @default.
• W2077397079 cites W2166990556 @default.
• W2077397079 cites W2167090216 @default.
• W2077397079 cites W2168094636 @default.
• W2077397079 cites W2169176338 @default.
• W2077397079 cites W2170669821 @default.
• W2077397079 cites W2331756487 @default.
• W2077397079 cites W2489096985 @default.
• W2077397079 cites W3208244841 @default.
• W2077397079 doi "https://doi.org/10.1128/jvi.02510-12" @default.
• W2077397079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3592143" @default.
• W2077397079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23283945" @default.
• W2077397079 hasPublicationYear "2013" @default.
• W2077397079 type Work @default.
• W2077397079 sameAs 2077397079 @default.
• W2077397079 citedByCount "41" @default.

• next