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- W2077399025 abstract "A series of hairpin oligomers containing benzimidazole (Bi) and imidazopyridine (Ip) rings were synthesized and screened to target 5'-WGGGGW-3', a core sequence in the DNA-binding site of NF-kappaB, a prolific transcription factor important in biology and disease. Five Bi and Ip containing oligomers bound to the 5'-WGGGGW-3' site with high affinity. One of the oligomers (Im-Im-Im-Im-gamma-Py-Bi-Py-Bi-beta-Dp) was able to inhibit DNA binding by the transcription factor NF-kappaB." @default.
- W2077399025 created "2016-06-24" @default.
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- W2077399025 date "2007-01-01" @default.
- W2077399025 modified "2023-09-28" @default.
- W2077399025 title "Programmable oligomers targeting 5′-GGGG-3′ in the minor groove of DNA and NF-κB binding inhibition" @default.
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- W2077399025 doi "https://doi.org/10.1016/j.bmc.2006.10.051" @default.
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