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- W2077403005 abstract "<h2>Abstract</h2> Irinotecan (CPT-11), a topoisomerase I inhibitor, has been shown in preclinical studies to be a potent radiosensitizer. Carboplatin, a known radiosensitizer with single-agent activity in non–small-cell lung cancer (NSCLC), is felt to be a rational choice in combination with irinotecan. We have completed the initial portion of a phase I study, in patients with locally unresectable lung cancer, combining irinotecan with thoracic radiation. Thirteen patients have been entered onto this study through three dose levels (30 to 50 mg/m<sup>2</sup>/week) of irinotecan. There were seven partial responses in 12 evaluable patients, for an overall response rate of 58%. Nausea, vomiting, and esophagitis were the principal toxicities of weekly irinotecan and concurrent thoracic radiation. As the maximum tolerated dose (MTD) of irinotecan with radiation has been established at 40 mg/m<sup>2</sup>/week, we are currently accruing patients to the second phase of this study with the addition of carboplatin (AUC = 2). Thus far toxicity has primarily been esophagitis." @default.
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- W2077403005 date "2000-05-01" @default.
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- W2077403005 title "A Phase I Trial of Outpatient Weekly Irinotecan/Carboplatin and Concurrent Radiation for Stage III Unresectable Non–Small-Cell Lung Cancer: A Vanderbilt-Ingram Cancer Center Affiliate Network Trial" @default.
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- W2077403005 doi "https://doi.org/10.3816/clc.2000.n.014" @default.
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