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• W2077413595 abstract "Norepinephrine (NE) has been shown to have a biphasic effect on evoked potentials in the CA1 region of the hippocampus of the rat in vitro, with a beta receptor mediating an increase and an alpha receptor eliciting a decrease in the amplitude of the population spike. The purpose of this study was to use selective alpha-adrenergic agonists and antagonists to determine the subtype of receptor mediating the depressant response of NE. The present investigations demonstrated that the selective alpha1 agonist, phenylephrine (2–50 μ M) elicited a dose-dependent depression of the amplitude of the population spike. Clonidine, a relatively selective alpha2-agonist, also depressed the amplitude of the population spike, but only at concentrations (10 μ M) that were inconsistent with a selective action upon alpha2-receptors. Another alpha2-agonist, alpha-methylnorepinephrine (100–400 nM) did not depress the amplitude of the population spike. The depressant effect of NE was antagonized by the nonselective alpha antagonist, phentolamine (0.5–50 μ M) and the alpha1-selective antagonist, prazosin (1 μ M), but not by the alpha2-selective antagonist, idazoxan (1–10 μ M). Phentolamine and prazosin antagonized the response to phenylephrine but not to clonidine. The depressant effect of NE was not antagonized by the antagonist of serotonin and dopamine, spiperone (100 nM); conversely, the effect of 8-hydroxy-2-(di-n-propylamine) tetralin (50 μ M), a 5-HTA receptor-selective agonist, which also depresses the amplitude of the population spike, was not antagonized by phentolamine (5 μ M). These data indicate that, in the in vitro slice preparation, NE acts upon an alpha1-adrenergic receptor to depress the amplitude of the population spike, and not an alpha2-adrenergic receptor, a 5-HT1A receptor or a dopamine receptor. The data also support the conclusion that serotonin acts independently to reduce the response of the hippocampal population spike." @default.
• W2077413595 created "2016-06-24" @default.
• W2077413595 creator A5050808660 @default.
• W2077413595 date "1988-04-01" @default.
• W2077413595 modified "2023-09-27" @default.
• W2077413595 title "Noradrenergic depression of synaptic responses in hippocampus of rat: Evidence for mediation by alpha1-receptors" @default.
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• W2077413595 doi "https://doi.org/10.1016/0028-3908(88)90148-7" @default.
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