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• W2077417862 abstract "Abstract Purpose To study the feasibility of an interleaved gradient‐echo, echo‐planar imaging (iGE‐EPI) sequence for multiplanar magnetic resonance temperature imaging (MRTI) to monitor intracerebral thermal treatment three‐dimensionally using multielement ultrasound applicators. Materials and Methods Transmissible venereal tumor (TVT) fragments were injected into the right cerebral hemisphere of five dogs. Guided by MRI, an interstitial ultrasound applicator was inserted into the tumor or normal brain tissue. The iGE‐EPI sequence was used to estimate temperature changes by computing the complex phase‐difference induced by temperature‐dependent shifts in the proton resonance frequency of water. The thermal dose maps were updated every 6–8 seconds for five to seven image planes during treatment. The results of MRTI were compared with those of post‐treatment MRI and histologic analysis. Results The multiplanar MRTI monitored temperature and thermal dose distributions in tumor and normal brain tissue over the entire user‐defined treatment volume. The ultrasound applicators produced contiguous areas of coagulative necrosis, resulting in 1.5–4.0 cm 3 volumes of tissue necrosis. MRTI‐based assessments of thermal‐dose distributions were consistent with the results of post‐treatment MRI and histologic analysis. Conclusion Multiplanar MRTI is feasible for measuring necrosing thermal doses during intracerebral thermal delivery by interstitial ultrasound applicators. J. Magn. Reson. Imaging 2002;16:522–531. © 2002 Wiley‐Liss, Inc." @default.
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• W2077417862 date "2002-10-28" @default.
• W2077417862 modified "2023-10-13" @default.
• W2077417862 title "Multiplanar MR temperature-sensitive imaging of cerebral thermal treatment using interstitial ultrasound applicators in a canine model" @default.
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• W2077417862 doi "https://doi.org/10.1002/jmri.10191" @default.
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