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• W2077426649 abstract "The amiloride-sensitive epithelial Na+ channel regulates Na+ homeostasis in cells. Recently, we described that the delta-subunit is a candidate molecule for a pH sensor in the human brain. Here, an N-terminal spliced variant of the delta-subunit is cloned from human brain, and designated as the delta2-subunit, which is expressed with the original delta-subunit (delta1-subunit) at the same level in the human brain. Functional analyses revealed that the physiological and pharmacological properties (interaction with accessory betagamma-subunits, activation by acidic pH, amiloride sensitivity) of the delta2-subunit were similar to those of the delta1-subunit. In conclusion, the activities of both subunits may be involved in the mechanism underlying pH sensing in the human brain." @default.
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• W2077426649 date "2006-10-01" @default.
• W2077426649 modified "2023-09-30" @default.
• W2077426649 title "A novel spliced variant of the epithelial Na+ channel δ-subunit in the human brain" @default.
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• W2077426649 doi "https://doi.org/10.1016/j.bbrc.2006.08.043" @default.
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