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- W2077427123 abstract "Interactions of isoniazid with magnesium oxide and with lactose were investigated in the solid state. In the isoniazidmagnesium oxide system, chemisorption as well as physical adsorption of isoniazid molecules onto the magnesium oxide surface was confirmed by diffuse reflectance spectroscopic data. An absorption maximum due to chemisorbed isoniazid molecules was found to occur at 325 mμ, whereas physical adsorption was detected at 268 mμ. The mechanism of surface chemisorption is different from that of the formation of the isoniazid-metal-ion complex in solution. The browning reaction of the isoniazid-lactose system in solid state was also studied using diffuse reflectance spectroscopy. The rates of browning at 95, 100, 105, and 110° were followed by measuring the reflectance at 450 mμ. From the data obtained, the approximate time needed for browning to be perceptible has been predicted. TLC separations of the reaction products confirmed the presence of isonicotinoyl hydrazones of lactose and hydroxymethylfurfural." @default.
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- W2077427123 title "Interaction of Isoniazid with Magnesium Oxide and Lactose" @default.
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- W2077427123 doi "https://doi.org/10.1002/jps.2600590903" @default.
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