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- W2077433526 abstract "Small joint periarticular erosions have occupied center stage in the understanding of the pathogenesis of rheumatoid arthritis (RA) for well over 50 years (1). Such erosions have diagnostic and prognostic significance and have served as a valuable outcome measure in the evaluation of therapeutic responses to drugs for disease (2). The RA erosion paradigm extends well beyond these immediately clinically relevant issues. An understanding of the proinflammatory milieu at the cartilage–pannus junction, the putative site where erosion formation was thought to be initiated, was considered to represent a key event toward the development of biologic therapies in RA (3). Ongoing efforts seek to link the immunopathogenetic basis for erosion formation to emergent genome-wide association studies to further elucidate the basis for joint disease in RA. The importance of erosions in the immunopathogenesis of RA is almost dwarfed by the importance that their early detection has assumed. Erosions represent 1 of the 3 diagnostic criteria for RA when combined with clinical and serologic parameters (2). With the advent of more sophisticated imaging techniques, most notably, magnetic resonance imaging (MRI) and ultrasound (US), rheumatologists are increasingly interested in detecting these seemingly diagnostic and prognostic features in early RA to facilitate a definitive diagnosis and to initiate the most appropriate therapy, at the earliest possible opportunity. Why this is the case and why it merits reconsideration based on work reported by Stach et al in this issue of Arthritis & Rheumatism (4) and based on other recent data are the subjects of this perspective. History of erosion immunopathogenesis" @default.
- W2077433526 created "2016-06-24" @default.
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- W2077433526 date "2010-01-28" @default.
- W2077433526 modified "2023-10-13" @default.
- W2077433526 title "The history of erosions in rheumatoid arthritis: Are erosions history?" @default.
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- W2077433526 doi "https://doi.org/10.1002/art.27199" @default.
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