Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077436250> ?p ?o ?g. }
- W2077436250 endingPage "1980" @default.
- W2077436250 startingPage "1972" @default.
- W2077436250 abstract "Antibiotic resistance is a growing global problem, with very few new compounds in development. Bacterial transcription is an underutilized target for antibiotics, which has been attributed to the similarity of the active site of RNA polymerases (RNAPs) across all domains of life and the ease with which resistance can arise through point mutation at multiple sites within this conserved region. In this study we have taken a rational approach to design a novel set of compounds that specifically target the formation of transcription initiation complexes by preventing the unique bacterial σ initiation factor from binding to RNAP. We have identified the region of RNAP to which these compounds bind and demonstrate that one compound, GKL003, has an inhibition constant in the low nanomolar range. This compound has activity against both Gram-positive and -negative organisms, including a community acquired methicillin-resistant strain of the major pathogen Staphylococcus aureus." @default.
- W2077436250 created "2016-06-24" @default.
- W2077436250 creator A5011528808 @default.
- W2077436250 creator A5016735101 @default.
- W2077436250 creator A5017276071 @default.
- W2077436250 creator A5018259050 @default.
- W2077436250 creator A5022896199 @default.
- W2077436250 creator A5036634694 @default.
- W2077436250 creator A5052900867 @default.
- W2077436250 creator A5073158351 @default.
- W2077436250 date "2013-07-05" @default.
- W2077436250 modified "2023-10-16" @default.
- W2077436250 title "Inhibitors of Bacterial Transcription Initiation Complex Formation" @default.
- W2077436250 cites W1675887579 @default.
- W2077436250 cites W1970785273 @default.
- W2077436250 cites W1978522349 @default.
- W2077436250 cites W1984774876 @default.
- W2077436250 cites W1989209749 @default.
- W2077436250 cites W1989880994 @default.
- W2077436250 cites W2006373999 @default.
- W2077436250 cites W2009608230 @default.
- W2077436250 cites W2025413826 @default.
- W2077436250 cites W2043552705 @default.
- W2077436250 cites W2045597092 @default.
- W2077436250 cites W2053475634 @default.
- W2077436250 cites W2055506322 @default.
- W2077436250 cites W2090247097 @default.
- W2077436250 cites W2107870109 @default.
- W2077436250 cites W2113555445 @default.
- W2077436250 cites W2120061656 @default.
- W2077436250 cites W2137749088 @default.
- W2077436250 cites W2145059589 @default.
- W2077436250 cites W2148661446 @default.
- W2077436250 cites W2157018267 @default.
- W2077436250 cites W2163876139 @default.
- W2077436250 cites W2312201585 @default.
- W2077436250 cites W2793938485 @default.
- W2077436250 cites W4249909638 @default.
- W2077436250 doi "https://doi.org/10.1021/cb400231p" @default.
- W2077436250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23751807" @default.
- W2077436250 hasPublicationYear "2013" @default.
- W2077436250 type Work @default.
- W2077436250 sameAs 2077436250 @default.
- W2077436250 citedByCount "50" @default.
- W2077436250 countsByYear W20774362502014 @default.
- W2077436250 countsByYear W20774362502015 @default.
- W2077436250 countsByYear W20774362502016 @default.
- W2077436250 countsByYear W20774362502017 @default.
- W2077436250 countsByYear W20774362502018 @default.
- W2077436250 countsByYear W20774362502019 @default.
- W2077436250 countsByYear W20774362502020 @default.
- W2077436250 countsByYear W20774362502021 @default.
- W2077436250 countsByYear W20774362502022 @default.
- W2077436250 countsByYear W20774362502023 @default.
- W2077436250 crossrefType "journal-article" @default.
- W2077436250 hasAuthorship W2077436250A5011528808 @default.
- W2077436250 hasAuthorship W2077436250A5016735101 @default.
- W2077436250 hasAuthorship W2077436250A5017276071 @default.
- W2077436250 hasAuthorship W2077436250A5018259050 @default.
- W2077436250 hasAuthorship W2077436250A5022896199 @default.
- W2077436250 hasAuthorship W2077436250A5036634694 @default.
- W2077436250 hasAuthorship W2077436250A5052900867 @default.
- W2077436250 hasAuthorship W2077436250A5073158351 @default.
- W2077436250 hasConcept C104317684 @default.
- W2077436250 hasConcept C138885662 @default.
- W2077436250 hasConcept C179926584 @default.
- W2077436250 hasConcept C26261996 @default.
- W2077436250 hasConcept C2776449523 @default.
- W2077436250 hasConcept C2779489039 @default.
- W2077436250 hasConcept C41895202 @default.
- W2077436250 hasConcept C47319516 @default.
- W2077436250 hasConcept C501593827 @default.
- W2077436250 hasConcept C523546767 @default.
- W2077436250 hasConcept C53105671 @default.
- W2077436250 hasConcept C54355233 @default.
- W2077436250 hasConcept C67705224 @default.
- W2077436250 hasConcept C82381507 @default.
- W2077436250 hasConcept C86339819 @default.
- W2077436250 hasConcept C86803240 @default.
- W2077436250 hasConcept C89423630 @default.
- W2077436250 hasConcept C95444343 @default.
- W2077436250 hasConceptScore W2077436250C104317684 @default.
- W2077436250 hasConceptScore W2077436250C138885662 @default.
- W2077436250 hasConceptScore W2077436250C179926584 @default.
- W2077436250 hasConceptScore W2077436250C26261996 @default.
- W2077436250 hasConceptScore W2077436250C2776449523 @default.
- W2077436250 hasConceptScore W2077436250C2779489039 @default.
- W2077436250 hasConceptScore W2077436250C41895202 @default.
- W2077436250 hasConceptScore W2077436250C47319516 @default.
- W2077436250 hasConceptScore W2077436250C501593827 @default.
- W2077436250 hasConceptScore W2077436250C523546767 @default.
- W2077436250 hasConceptScore W2077436250C53105671 @default.
- W2077436250 hasConceptScore W2077436250C54355233 @default.
- W2077436250 hasConceptScore W2077436250C67705224 @default.
- W2077436250 hasConceptScore W2077436250C82381507 @default.
- W2077436250 hasConceptScore W2077436250C86339819 @default.
- W2077436250 hasConceptScore W2077436250C86803240 @default.
- W2077436250 hasConceptScore W2077436250C89423630 @default.