FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077437334> ?p ?o ?g. }

• W2077437334 endingPage "689" @default.
• W2077437334 startingPage "679" @default.
• W2077437334 abstract "1 In cats anaesthetized with pentobarbitone, saxitoxin and, on a few occasions, tetrodotoxin were injected into a lateral cerebral ventricle or into the subarachnoid space of the lower brain stem. Observations were made on frequency and tidal volume of breathing, on CO(2) responsiveness and on electrical responsiveness of the respiratory centre. Effects on the blood pressure were observed simultaneously.2 A single large dose of toxin, e.g., 250 ng, produced within minutes apneustic breathing and a rise in blood pressure which were converted rapidly to respiratory failure and hypotension. In contrast, repeated small doses, e.g., 25 ng, yielded only progressive slowing of the respiration together with circulatory hypotension. Bulbar depression was produced as effectively by subarachnoid injection as by intraventricular injection of the toxins. Onset of action was detectable within seconds.3 Slowing of the respiration occurred independently of change in tidal volume and whether or not the vagus nerves were cut. The reduction in breathing frequency is attributed to direct toxin-induced depression of the central respiratory oscillator.4 Steady-state measurements of tidal volume at controlled levels of alveolar CO(2) pressure in intermediate stages of respiratory depression showed that the toxins produced an increase in CO(2) stimulation threshold as well as a reduction in gain of CO(2) responsiveness, whether or not the vagus nerves were cut. Carotid arterial chemoreceptor reactivity to O(2) was demonstrable when central sensitivity to CO(2) was depressed. These effects are attributed to a direct influence of the toxins upon the brainstem CO(2)-tidal volume controller.5 Responsiveness of the medullary inspiratory centre to electrical stimulation persisted after the failure of spontaneous breathing was caused by the toxins. Conversely, restitution of electrical responsiveness preceded the reappearance of spontaneous respiratory activity in the recovery phase of toxic depression. Circulatory effects paralleled the changes in respiratory behaviour.6 On the basis of the relatively prompt and discrete alterations in the central respiratory and circulatory control mechanisms produced by saxitoxin and tetrodotoxin placed in the cerebrospinal fluid, it is concluded that the agents rapidly penetrated to deep target loci in the lower brain stem." @default.
• W2077437334 created "2016-06-24" @default.
• W2077437334 creator A5041079132 @default.
• W2077437334 creator A5083435624 @default.
• W2077437334 date "1977-12-01" @default.
• W2077437334 modified "2023-10-16" @default.
• W2077437334 title "RESPIRATORY AND CIRCULATORY EFFECTS OF SAXITOXIN IN THE CEREBROSPINAL FLUID" @default.
• W2077437334 cites W1524958560 @default.
• W2077437334 cites W1796816418 @default.
• W2077437334 cites W1964540893 @default.
• W2077437334 cites W1968602053 @default.
• W2077437334 cites W1973160896 @default.
• W2077437334 cites W1977972097 @default.
• W2077437334 cites W1979532965 @default.
• W2077437334 cites W2001284157 @default.
• W2077437334 cites W2002542100 @default.
• W2077437334 cites W2029940303 @default.
• W2077437334 cites W2043199377 @default.
• W2077437334 cites W2070960170 @default.
• W2077437334 cites W2073397387 @default.
• W2077437334 cites W2074280166 @default.
• W2077437334 cites W2092717746 @default.
• W2077437334 cites W2172970060 @default.
• W2077437334 cites W2405810062 @default.
• W2077437334 cites W2410496873 @default.
• W2077437334 cites W2414550551 @default.
• W2077437334 cites W2416803909 @default.
• W2077437334 cites W2417604879 @default.
• W2077437334 cites W4238292646 @default.
• W2077437334 doi "https://doi.org/10.1111/j.1476-5381.1977.tb07561.x" @default.
• W2077437334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1668070" @default.
• W2077437334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/597670" @default.
• W2077437334 hasPublicationYear "1977" @default.
• W2077437334 type Work @default.
• W2077437334 sameAs 2077437334 @default.
• W2077437334 citedByCount "23" @default.
• W2077437334 countsByYear W20774373342014 @default.
• W2077437334 countsByYear W20774373342015 @default.
• W2077437334 countsByYear W20774373342019 @default.
• W2077437334 countsByYear W20774373342021 @default.
• W2077437334 countsByYear W20774373342022 @default.
• W2077437334 crossrefType "journal-article" @default.
• W2077437334 hasAuthorship W2077437334A5041079132 @default.
• W2077437334 hasAuthorship W2077437334A5083435624 @default.
• W2077437334 hasBestOaLocation W20774373342 @default.
• W2077437334 hasConcept C103247709 @default.
• W2077437334 hasConcept C105702510 @default.
• W2077437334 hasConcept C126322002 @default.
• W2077437334 hasConcept C127413603 @default.
• W2077437334 hasConcept C170493617 @default.
• W2077437334 hasConcept C182215343 @default.
• W2077437334 hasConcept C200457457 @default.
• W2077437334 hasConcept C2777257755 @default.
• W2077437334 hasConcept C2777449187 @default.
• W2077437334 hasConcept C2777953023 @default.
• W2077437334 hasConcept C2779651940 @default.
• W2077437334 hasConcept C2780906327 @default.
• W2077437334 hasConcept C42219234 @default.
• W2077437334 hasConcept C534529494 @default.
• W2077437334 hasConcept C71924100 @default.
• W2077437334 hasConcept C72859922 @default.
• W2077437334 hasConcept C78519656 @default.
• W2077437334 hasConcept C79959777 @default.
• W2077437334 hasConcept C8213797 @default.
• W2077437334 hasConcept C84393581 @default.
• W2077437334 hasConceptScore W2077437334C103247709 @default.
• W2077437334 hasConceptScore W2077437334C105702510 @default.
• W2077437334 hasConceptScore W2077437334C126322002 @default.
• W2077437334 hasConceptScore W2077437334C127413603 @default.
• W2077437334 hasConceptScore W2077437334C170493617 @default.
• W2077437334 hasConceptScore W2077437334C182215343 @default.
• W2077437334 hasConceptScore W2077437334C200457457 @default.
• W2077437334 hasConceptScore W2077437334C2777257755 @default.
• W2077437334 hasConceptScore W2077437334C2777449187 @default.
• W2077437334 hasConceptScore W2077437334C2777953023 @default.
• W2077437334 hasConceptScore W2077437334C2779651940 @default.
• W2077437334 hasConceptScore W2077437334C2780906327 @default.
• W2077437334 hasConceptScore W2077437334C42219234 @default.
• W2077437334 hasConceptScore W2077437334C534529494 @default.
• W2077437334 hasConceptScore W2077437334C71924100 @default.
• W2077437334 hasConceptScore W2077437334C72859922 @default.
• W2077437334 hasConceptScore W2077437334C78519656 @default.
• W2077437334 hasConceptScore W2077437334C79959777 @default.
• W2077437334 hasConceptScore W2077437334C8213797 @default.
• W2077437334 hasConceptScore W2077437334C84393581 @default.
• W2077437334 hasIssue "4" @default.
• W2077437334 hasLocation W20774373341 @default.
• W2077437334 hasLocation W20774373342 @default.
• W2077437334 hasLocation W20774373343 @default.
• W2077437334 hasLocation W20774373344 @default.
• W2077437334 hasOpenAccess W2077437334 @default.
• W2077437334 hasPrimaryLocation W20774373341 @default.
• W2077437334 hasRelatedWork W2013013378 @default.
• W2077437334 hasRelatedWork W2016543724 @default.
• W2077437334 hasRelatedWork W2019190204 @default.
• W2077437334 hasRelatedWork W2020725587 @default.
• W2077437334 hasRelatedWork W2037755837 @default.
• W2077437334 hasRelatedWork W2064275912 @default.

• next