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• W2077438169 abstract "The detection of biological molecules and their interactions is a significant component of modern biomedical research. In current biosensor technologies, simultaneous detection is limited to a small number of analytes by the spectral overlap of their signals. We have developed an NMR-based xenon biosensor that capitalizes on the enhanced signal-to-noise, spectral simplicity, and chemical-shift sensitivity of laser-polarized xenon to detect specific biomolecules at the level of tens of nanomoles. We present results using xenon functionalized by a biotin-modified supramolecular cage to detect biotin-avidin binding. This biosensor methodology can be extended to a multiplexing assay for multiple analytes." @default.
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• W2077438169 date "2001-09-04" @default.
• W2077438169 modified "2023-10-16" @default.
• W2077438169 title "Functionalized xenon as a biosensor" @default.
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• W2077438169 doi "https://doi.org/10.1073/pnas.191368398" @default.
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