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• W2077438223 abstract "We demonstrate a complete nanotube electrophoresis system (nanotube radii in the range of 50 to 150 nm) based on lipid membranes, comprising DNA injection, single-molecule transport, and single-molecule detection. Using gel-capped electrodes, electrophoretic single-file transport of fluorescently labeled dsDNA molecules is observed inside nanotubes. The strong confinement to a channel of molecular dimensions ensures a detection efficiency close to unity and identification of DNA size from its linear relation to the integrated peak intensity. In addition to constituting a nanotechnological device for identification and quantification of single macromolecules or biopolymers, this system provides a method to study their conformational dynamics, reaction kinetics, and transport in cell-like environments." @default.
• W2077438223 created "2016-06-24" @default.
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• W2077438223 date "2005-06-16" @default.
• W2077438223 modified "2023-09-25" @default.
• W2077438223 title "Single-file electrophoretic transport and counting of individual DNA molecules in surfactant nanotubes" @default.
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• W2077438223 doi "https://doi.org/10.1073/pnas.0500081102" @default.
• W2077438223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1166592" @default.
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