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• W2077440018 endingPage "E254" @default.
• W2077440018 startingPage "E239" @default.
• W2077440018 abstract "The corneal endothelium maintains stromal deturgescence, which is a prerequisite for corneal transparency. The principal challenge to stromal deturgescence is the swelling pressure associated with the hydrophilic glycosaminoglycans in the stroma. This negative pressure induces fluid leak into the stroma from the anterior chamber, but the rate of leak is restrained by the tight junctions of the endothelium. This role of the endothelium represents its barrier function. In healthy cornea, the fluid leak is counterbalanced by an active fluid pump mechanism associated with the endothelium itself. Although this pump-leak hypothesis was postulated several decades ago, the mechanisms underlying regulation of the balance between the pump and leak functions remain largely unknown. In the last couple of decades, the ion transport systems that support the fluid pump activity have been discovered. In contrast, despite significant evidence for corneal edema secondary to endothelial barrier dysfunction, the molecular aspects underlying its regulation are relatively unknown. Recent findings in our laboratory, however, indicate that barrier integrity (i.e., structural and functional integrity of the tight junctions) of the endothelium is sensitive to remodeling of its peri-junctional actomyosin ring, which is located at the apical junctional complex. This review provides a focused perspective on dynamic regulation of the barrier integrity of endothelium vis-à-vis plasticity of the peri-junctional actomyosin ring and its association with cell signaling downstream of small GTPases of the Rho family. Based on findings to date, it appears that development of specific pharmacological strategies to treat corneal edema in response to inflammatory stress would be possible in the near future." @default.
• W2077440018 created "2016-06-24" @default.
• W2077440018 creator A5075822195 @default.
• W2077440018 date "2010-04-01" @default.
• W2077440018 modified "2023-09-26" @default.
• W2077440018 title "Dynamic Regulation of Barrier Integrity of the Corneal Endothelium" @default.
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• W2077440018 doi "https://doi.org/10.1097/opx.0b013e3181d39464" @default.
• W2077440018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2868144" @default.
• W2077440018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20142793" @default.
• W2077440018 hasPublicationYear "2010" @default.
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