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- W2077441950 abstract "To determine if the subcutaneous injection of the gonadotropin releasing hormone (GnRH) agonist (a), leuprolide acetate, 3 days after embryo transfer (ET) can improve pregnancy rates in donor oocyte recipients. Prospective cohort comparison study. A prospective study was initiated in which recipients were offered to participate in a research study evaluating whether 1mg s.c. of leuprolide acetate 3 days after ET may improve pregnancy rates. There was no financial award for participating but they were made aware of preliminary data in women undergoing in vitro fertilization (IVF)-ET where improved pregnancy rates were found with its use. The study period was 2 years. The first serum beta human chorionic gonadotropin (hCG) level was compared as well as pregnancy rates in those agreeing to participate vs. those unwilling. There were 36 women choosing to use leuprolide and 76 did not. The clinical pregnancy rate (ultrasound evidence of live fetus at 8 weeks) was 63.9% (23/36) for those taking vs. 39.5% (30/76) for those not taking the drugs (p=0.027). The live delivered pregnancy rate per transfer was 52.8% (19/36) vs. 32.9% (15/76). Chi-square analysis showed p=0.0009. The implantation rates were 44.2% (34/77) vs. 25.2%, respectively. The average first serum beta-hCG level was 294 mIU/mL vs. 325 mIU/mL (p>.05, ANOVA). These preliminary data need to be confirmed by a larger study and by other IVF centers. If confirmed the mechanism for improvement does not seem related to increased level of hCG. A direct agonistic effect on GnRH receptors in the endometrium is hypothesized." @default.
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- W2077441950 date "2013-09-01" @default.
- W2077441950 modified "2023-09-27" @default.
- W2077441950 title "Improved implantation and live delivered pregnancy rates following transfer of embryos derived from donor oocytes by single injection of leuprolide in mid-luteal phase" @default.
- W2077441950 doi "https://doi.org/10.1016/j.fertnstert.2013.07.1027" @default.
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