Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077453340> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2077453340 abstract "Liverworts (Marchantiophyta, Hepaticae) belong to the bryophytes and comprise of about six to eight thousand species which are distributed everywhere in the world. Although being the structurally most primitive of the terrestrial plants they produce a complex array of secondary metabolites, including a number of mono- sesqui- and diterpenoids and also aromatic compounds like bibenzyls and bis (bibenzyls). Studies have demonstrated that several of these compounds possess a wide range of interesting biological activities, for instance inhibitory activity against cancer cells. Herein, the inhibiting effects of extracts and fractions from two different Icelandic liverworts were investigated on cancer cell-lines in vitro. Chiloscyphus pallescens and Marchantia polymorpha were collected in Iceland. Diethyl ether extracts were prepared and they were further fractionated on VLC (Vacuum Liquid Chromatography) with a n-hexane:ethyl acetate gradient. The inhibitory effects of the extracts and selected fractions were tested in four concentrations 80, 40, 20 and 10µg/ml, on the cancer cell-lines MCF-7 and T47D. Results were obtained as% viable cells by crystal violet staining. Extracts and fractions from both liverwort species demonstrated dose-dependent inhibitory effects onto cell growth, viability and colony formation ability of the cancer cells in vitro. One fraction from each liverwort showed the highest activity with approximate IC50 20µg/ml. Bioguided isolation of active constituents from these fractions is in progress." @default.
- W2077453340 created "2016-06-24" @default.
- W2077453340 creator A5002093381 @default.
- W2077453340 creator A5017999296 @default.
- W2077453340 creator A5020734267 @default.
- W2077453340 creator A5024556133 @default.
- W2077453340 date "2010-08-24" @default.
- W2077453340 modified "2023-10-18" @default.
- W2077453340 title "Bioprospecting Icelandic liverworts for anticancer activity" @default.
- W2077453340 doi "https://doi.org/10.1055/s-0030-1264357" @default.
- W2077453340 hasPublicationYear "2010" @default.
- W2077453340 type Work @default.
- W2077453340 sameAs 2077453340 @default.
- W2077453340 citedByCount "0" @default.
- W2077453340 crossrefType "journal-article" @default.
- W2077453340 hasAuthorship W2077453340A5002093381 @default.
- W2077453340 hasAuthorship W2077453340A5017999296 @default.
- W2077453340 hasAuthorship W2077453340A5020734267 @default.
- W2077453340 hasAuthorship W2077453340A5024556133 @default.
- W2077453340 hasConcept C104317684 @default.
- W2077453340 hasConcept C121608353 @default.
- W2077453340 hasConcept C157369684 @default.
- W2077453340 hasConcept C185592680 @default.
- W2077453340 hasConcept C202751555 @default.
- W2077453340 hasConcept C2776905955 @default.
- W2077453340 hasConcept C2777695334 @default.
- W2077453340 hasConcept C2779858419 @default.
- W2077453340 hasConcept C54355233 @default.
- W2077453340 hasConcept C55493867 @default.
- W2077453340 hasConcept C59822182 @default.
- W2077453340 hasConcept C86803240 @default.
- W2077453340 hasConcept C96232424 @default.
- W2077453340 hasConceptScore W2077453340C104317684 @default.
- W2077453340 hasConceptScore W2077453340C121608353 @default.
- W2077453340 hasConceptScore W2077453340C157369684 @default.
- W2077453340 hasConceptScore W2077453340C185592680 @default.
- W2077453340 hasConceptScore W2077453340C202751555 @default.
- W2077453340 hasConceptScore W2077453340C2776905955 @default.
- W2077453340 hasConceptScore W2077453340C2777695334 @default.
- W2077453340 hasConceptScore W2077453340C2779858419 @default.
- W2077453340 hasConceptScore W2077453340C54355233 @default.
- W2077453340 hasConceptScore W2077453340C55493867 @default.
- W2077453340 hasConceptScore W2077453340C59822182 @default.
- W2077453340 hasConceptScore W2077453340C86803240 @default.
- W2077453340 hasConceptScore W2077453340C96232424 @default.
- W2077453340 hasIssue "12" @default.
- W2077453340 hasLocation W20774533401 @default.
- W2077453340 hasOpenAccess W2077453340 @default.
- W2077453340 hasPrimaryLocation W20774533401 @default.
- W2077453340 hasRelatedWork W1974105642 @default.
- W2077453340 hasRelatedWork W2034433732 @default.
- W2077453340 hasRelatedWork W2131677966 @default.
- W2077453340 hasRelatedWork W2409674730 @default.
- W2077453340 hasRelatedWork W2763628303 @default.
- W2077453340 hasRelatedWork W2984847388 @default.
- W2077453340 hasRelatedWork W2986367273 @default.
- W2077453340 hasRelatedWork W3054323297 @default.
- W2077453340 hasRelatedWork W4240311198 @default.
- W2077453340 hasRelatedWork W4298087472 @default.
- W2077453340 hasVolume "76" @default.
- W2077453340 isParatext "false" @default.
- W2077453340 isRetracted "false" @default.
- W2077453340 magId "2077453340" @default.
- W2077453340 workType "article" @default.