FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077454531> ?p ?o ?g. }

• W2077454531 endingPage "7999" @default.
• W2077454531 startingPage "7995" @default.
• W2077454531 abstract "The gene for the RNA-dependent eIF-2 alpha protein kinase (PKR) was isolated from mouse genomic DNA and characterized. The mouse PKR gene contains 16 exons and spans about 28 kilobase pairs. Exon 1 is untranslated; the AUG translation initiation site is located early in the second exon. Exon 16 includes the UAG translation termination site. ATTAAA polyadenylylation signal, and a putative TA rather than CA 3' cleavage site. Primer extension analysis determined one major as well as multiple minor transcription initiation sites; the major site was 159 bp upstream of the translation initiation site. The complete cDNA of mouse PKR is, therefore, 2334 bp in length excluding the 3' poly(A)+ tail. The PKR gene 5' flanking region was a functional promoter in interferon-treated, transfected cells as measured with chloramphenicol acetyltransferase as the reporter gene. Sequence analysis of the 5' flanking region disclosed numerous potential binding sites for transcription factors including both an ISRE element and a GAS element involved in interferon inducibility; Ets, Myb, MyoD, and E2F sites commonly associated with growth control regulation and differentiation; and NF-kappa B-like sites as well as sites for two types of interleukin 6-activated factors, NF-IL6 and APRF, often associated with acute-phase, immune, and inflammatory response genes." @default.
• W2077454531 created "2016-06-24" @default.
• W2077454531 creator A5031909976 @default.
• W2077454531 creator A5069329602 @default.
• W2077454531 date "1994-08-16" @default.
• W2077454531 modified "2023-09-27" @default.
• W2077454531 title "Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase." @default.
• W2077454531 cites W1221384716 @default.
• W2077454531 cites W1544086082 @default.
• W2077454531 cites W1545795848 @default.
• W2077454531 cites W1548864578 @default.
• W2077454531 cites W1549105044 @default.
• W2077454531 cites W1600092335 @default.
• W2077454531 cites W179070074 @default.
• W2077454531 cites W179818011 @default.
• W2077454531 cites W1805954825 @default.
• W2077454531 cites W1952468142 @default.
• W2077454531 cites W1969600436 @default.
• W2077454531 cites W1970812281 @default.
• W2077454531 cites W1971290197 @default.
• W2077454531 cites W1972211816 @default.
• W2077454531 cites W1975967072 @default.
• W2077454531 cites W1990474286 @default.
• W2077454531 cites W1990989603 @default.
• W2077454531 cites W1999156595 @default.
• W2077454531 cites W1999876280 @default.
• W2077454531 cites W2024437842 @default.
• W2077454531 cites W2034736009 @default.
• W2077454531 cites W2036853011 @default.
• W2077454531 cites W2040500676 @default.
• W2077454531 cites W2048243026 @default.
• W2077454531 cites W2048465699 @default.
• W2077454531 cites W2050717506 @default.
• W2077454531 cites W2056666301 @default.
• W2077454531 cites W2060333964 @default.
• W2077454531 cites W2060962038 @default.
• W2077454531 cites W2063450941 @default.
• W2077454531 cites W2064740655 @default.
• W2077454531 cites W2070857656 @default.
• W2077454531 cites W2081687035 @default.
• W2077454531 cites W2087709298 @default.
• W2077454531 cites W2087844645 @default.
• W2077454531 cites W2089033636 @default.
• W2077454531 cites W2091239909 @default.
• W2077454531 cites W2091315522 @default.
• W2077454531 cites W2091548699 @default.
• W2077454531 cites W2110237217 @default.
• W2077454531 cites W2115798976 @default.
• W2077454531 cites W2116387633 @default.
• W2077454531 cites W2138270253 @default.
• W2077454531 cites W2157589212 @default.
• W2077454531 cites W2173963963 @default.
• W2077454531 cites W2177943720 @default.
• W2077454531 cites W2230705365 @default.
• W2077454531 doi "https://doi.org/10.1073/pnas.91.17.7995" @default.
• W2077454531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/44531" @default.
• W2077454531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7914700" @default.
• W2077454531 hasPublicationYear "1994" @default.
• W2077454531 type Work @default.
• W2077454531 sameAs 2077454531 @default.
• W2077454531 citedByCount "110" @default.
• W2077454531 countsByYear W20774545312012 @default.
• W2077454531 countsByYear W20774545312014 @default.
• W2077454531 countsByYear W20774545312016 @default.
• W2077454531 countsByYear W20774545312019 @default.
• W2077454531 countsByYear W20774545312020 @default.
• W2077454531 countsByYear W20774545312021 @default.
• W2077454531 countsByYear W20774545312022 @default.
• W2077454531 crossrefType "journal-article" @default.
• W2077454531 hasAuthorship W2077454531A5031909976 @default.
• W2077454531 hasAuthorship W2077454531A5069329602 @default.
• W2077454531 hasBestOaLocation W20774545312 @default.
• W2077454531 hasConcept C101762097 @default.
• W2077454531 hasConcept C104317684 @default.
• W2077454531 hasConcept C132376346 @default.
• W2077454531 hasConcept C138885662 @default.
• W2077454531 hasConcept C150194340 @default.
• W2077454531 hasConcept C153911025 @default.
• W2077454531 hasConcept C161238802 @default.
• W2077454531 hasConcept C161733203 @default.
• W2077454531 hasConcept C179926584 @default.
• W2077454531 hasConcept C184235292 @default.
• W2077454531 hasConcept C194857396 @default.
• W2077454531 hasConcept C2780730277 @default.
• W2077454531 hasConcept C36823959 @default.
• W2077454531 hasConcept C41895202 @default.
• W2077454531 hasConcept C54355233 @default.
• W2077454531 hasConcept C67705224 @default.
• W2077454531 hasConcept C82495950 @default.
• W2077454531 hasConcept C86803240 @default.
• W2077454531 hasConcept C97029542 @default.
• W2077454531 hasConceptScore W2077454531C101762097 @default.
• W2077454531 hasConceptScore W2077454531C104317684 @default.
• W2077454531 hasConceptScore W2077454531C132376346 @default.
• W2077454531 hasConceptScore W2077454531C138885662 @default.
• W2077454531 hasConceptScore W2077454531C150194340 @default.
• W2077454531 hasConceptScore W2077454531C153911025 @default.
• W2077454531 hasConceptScore W2077454531C161238802 @default.

• next