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• W2077454906 abstract "Background The activity of alpha-2-antiplasmin (α2AP), the main fibrinolytic inhibitor, is modified by N- and C-terminal proteolytic cleavages. C-terminal cleavage converts plasminogen-binding α2AP (PB-α2AP) into a non-plasminogen-binding derivative. N-terminal cleavage by antiplasmin-cleaving enzyme (APCE), a soluble, circulating derivative of fibroblast activation protein (FAP), turns native Met-α2AP into Asn-α2AP, which is more quickly crosslinked into fibrin. Objectives We developed two novel enzyme-linked immunosorbent assays (ELISAs) to determine the N-terminal variation of α2AP to test the hypothesis that liver cirrhosis, characterized by increased expression of FAP/APCE, results in increased N-terminal cleavage of α2AP. Patients/Methods α2AP and FAP/APCE antigen levels were measured in the plasma samples of 75 patients with cirrhosis with different severities and 30 healthy control individuals. The percentage of N-terminal cleavage of α2AP was calculated. Results Compared with levels (median [interquartile range]) in control individuals, total PB-α2AP levels and Met-PB-α2AP levels were reduced in cirrhosis patients (27.3 [21.4–41.3] μg mL−1 vs. 56.2 [49.6–62.8] μg mL−1, P < 0.001, and 2.7 [1.7–5.5] μg mL−1 vs. 12.1 [11.0–15.3] μg mL−1, P < 0.001, respectively). Interestingly, the percentage of N-terminal cleavage was increased in the patients (87.8 [85.0–91.6]% vs. 77.2 [72.2–79.8]% in controls, P < 0.001), as well as the plasma FAP/APCE levels (166 [60–550] ng mL−1 in patients vs. 107 [67–157] ng mL−1 in controls, P < 0.001). Additionally, all variables significantly correlated with the severity of disease. Conclusions Using our novel ELISAs we found increased N-terminal cleavage of α2AP in liver cirrhosis patients, which correlated with the severity of disease and is likely to have reflected the increased FAP/APCE levels in these patients." @default.
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• W2077454906 date "2013-11-01" @default.
• W2077454906 modified "2023-09-30" @default.
• W2077454906 title "Increased N‐terminal cleavage of alpha‐2‐antiplasmin in patients with liver cirrhosis" @default.
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• W2077454906 doi "https://doi.org/10.1111/jth.12396" @default.
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