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• W2077455826 abstract "The development of the nervous system is a highly organized process involving the precise and coordinated timing of many complex events. These events require proper expression of genes promoting survival, differentiation, and maturation, but also repression of alternative cell fates and restriction of cell-type-specific gene expression. As the enzymes mediating post-translational histone acetylation and methylation are regulating higher order chromatin structure and controlling gene transcription, knowledge of the roles for these enzymes becomes crucial for understanding neural development and disease. The widespread expression and general biological roles for chromatin-modifying factors have hampered the studies of such enzymes in neural development, but in recent years, in vivo and in vitro studies have started to shed light on the various processes these enzymes regulate. In this review we summarize the implications of chromatin-modifying enzymes in neural development, with particular emphasis on enzymes regulating histone acetylation and methylation. Enzymes controlling histone acetylation and methylation are involved in the whole process of neural development, from controlling proliferation and undifferentiated, “poised”, state of stem cells to promoting and inhibiting neurogenic and gliogenic pathways and neuronal survival as well as neurite outgrowth. Aberrant enzymatic activities of histone acetyl transferases, deacetylases, and demethylases have been chemically and genetically associated with neural developmental disorders and cancer. Future studies may aim at linking the genetic and developmental studies to more in-depth biochemical characterization to provide a clearer picture of how to improve the diagnosis, prognosis, and treatment of such disorders. This article is part of a Special Issue entitled Biochemistry of Stem Cells." @default.
• W2077455826 created "2016-06-24" @default.
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• W2077455826 date "2013-02-01" @default.
• W2077455826 modified "2023-10-17" @default.
• W2077455826 title "Like a rolling histone: Epigenetic regulation of neural stem cells and brain development by factors controlling histone acetylation and methylation" @default.
• W2077455826 cites W1847634070 @default.
• W2077455826 cites W1963542234 @default.
• W2077455826 cites W1965425054 @default.
• W2077455826 cites W1966516467 @default.
• W2077455826 cites W1971561248 @default.
• W2077455826 cites W1973279069 @default.
• W2077455826 cites W1976507388 @default.
• W2077455826 cites W1978566481 @default.
• W2077455826 cites W1980730318 @default.
• W2077455826 cites W1985102214 @default.
• W2077455826 cites W1989164058 @default.
• W2077455826 cites W1990452435 @default.
• W2077455826 cites W1994514343 @default.
• W2077455826 cites W1996277745 @default.
• W2077455826 cites W1999146187 @default.
• W2077455826 cites W2000519327 @default.
• W2077455826 cites W2002676132 @default.
• W2077455826 cites W2011098156 @default.
• W2077455826 cites W2013785611 @default.
• W2077455826 cites W2016024994 @default.
• W2077455826 cites W2025543362 @default.
• W2077455826 cites W2027413271 @default.
• W2077455826 cites W2036903341 @default.
• W2077455826 cites W2038253485 @default.
• W2077455826 cites W2038439057 @default.
• W2077455826 cites W2044551569 @default.
• W2077455826 cites W2047661701 @default.
• W2077455826 cites W2048619491 @default.
• W2077455826 cites W2052572393 @default.
• W2077455826 cites W2054643318 @default.
• W2077455826 cites W2054835199 @default.
• W2077455826 cites W2058295483 @default.
• W2077455826 cites W2059059097 @default.
• W2077455826 cites W2059487779 @default.
• W2077455826 cites W2062345287 @default.
• W2077455826 cites W2062809474 @default.
• W2077455826 cites W2063430478 @default.
• W2077455826 cites W2068157186 @default.
• W2077455826 cites W2070187535 @default.
• W2077455826 cites W2072793384 @default.
• W2077455826 cites W2073539157 @default.
• W2077455826 cites W2077981176 @default.
• W2077455826 cites W2079262483 @default.
• W2077455826 cites W2085114914 @default.
• W2077455826 cites W2088335689 @default.
• W2077455826 cites W2089166549 @default.
• W2077455826 cites W2091508315 @default.
• W2077455826 cites W2091579735 @default.
• W2077455826 cites W2093318209 @default.
• W2077455826 cites W2094395614 @default.
• W2077455826 cites W2096048849 @default.
• W2077455826 cites W2096083625 @default.
• W2077455826 cites W2099067892 @default.
• W2077455826 cites W2102444784 @default.
• W2077455826 cites W2103774785 @default.
• W2077455826 cites W2103813902 @default.
• W2077455826 cites W2109106721 @default.
• W2077455826 cites W2109363432 @default.
• W2077455826 cites W2110938577 @default.
• W2077455826 cites W2115818350 @default.
• W2077455826 cites W2116387269 @default.
• W2077455826 cites W2117691193 @default.
• W2077455826 cites W2123453097 @default.
• W2077455826 cites W2134052811 @default.
• W2077455826 cites W2135785283 @default.
• W2077455826 cites W2137296349 @default.
• W2077455826 cites W2139610636 @default.
• W2077455826 cites W2140815401 @default.
• W2077455826 cites W2145544638 @default.
• W2077455826 cites W2146821633 @default.
• W2077455826 cites W2152052588 @default.
• W2077455826 cites W2164316007 @default.
• W2077455826 cites W2165903668 @default.
• W2077455826 cites W2166984732 @default.
• W2077455826 cites W2168448928 @default.
• W2077455826 cites W2170760271 @default.
• W2077455826 cites W2171590436 @default.
• W2077455826 cites W2198199336 @default.
• W2077455826 cites W4212766227 @default.
• W2077455826 doi "https://doi.org/10.1016/j.bbagen.2012.08.011" @default.
• W2077455826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22986149" @default.
• W2077455826 hasPublicationYear "2013" @default.
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