Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077458217> ?p ?o ?g. }
- W2077458217 endingPage "240" @default.
- W2077458217 startingPage "217" @default.
- W2077458217 abstract "Raman and Fourier transform IR (FTIR) microspectroscopic images of biological material (tissue sections) contain detailed information about their chemical composition. The challenge lies in identifying changes in chemical composition, as well as locating and assigning these changes to different conditions (pathology, anatomy, environmental or genetic factors). Multivariate data analysis techniques are ideal for decrypting such information from the data. This protocol provides a user-friendly pipeline and graphical user interface (GUI) for data pre-processing and unmixing of pixel spectra into their contributing pure components by multivariate curve resolution-alternating least squares (MCR-ALS) analysis. The analysis considers the full spectral profile in order to identify the chemical compounds and to visualize their distribution across the sample to categorize chemically distinct areas. Results are rapidly achieved (usually <30-60 min per image), and they are easy to interpret and evaluate both in terms of chemistry and biology, making the method generally more powerful than principal component analysis (PCA) or heat maps of single-band intensities. In addition, chemical and biological evaluation of the results by means of reference matching and segmentation maps (based on k-means clustering) is possible." @default.
- W2077458217 created "2016-06-24" @default.
- W2077458217 creator A5021463634 @default.
- W2077458217 creator A5048992309 @default.
- W2077458217 creator A5053552375 @default.
- W2077458217 creator A5062345597 @default.
- W2077458217 creator A5062928139 @default.
- W2077458217 creator A5087549132 @default.
- W2077458217 date "2015-01-08" @default.
- W2077458217 modified "2023-10-10" @default.
- W2077458217 title "Vibrational spectroscopic image analysis of biological material using multivariate curve resolution–alternating least squares (MCR-ALS)" @default.
- W2077458217 cites W1949502573 @default.
- W2077458217 cites W1970803484 @default.
- W2077458217 cites W1978819209 @default.
- W2077458217 cites W1979864442 @default.
- W2077458217 cites W1981735509 @default.
- W2077458217 cites W1984735140 @default.
- W2077458217 cites W1989441983 @default.
- W2077458217 cites W1989791337 @default.
- W2077458217 cites W1992791257 @default.
- W2077458217 cites W1993419109 @default.
- W2077458217 cites W2000355855 @default.
- W2077458217 cites W2000739842 @default.
- W2077458217 cites W2019188892 @default.
- W2077458217 cites W2020873958 @default.
- W2077458217 cites W2024173979 @default.
- W2077458217 cites W2035244841 @default.
- W2077458217 cites W2035381599 @default.
- W2077458217 cites W2039902016 @default.
- W2077458217 cites W2041872083 @default.
- W2077458217 cites W2045578732 @default.
- W2077458217 cites W2060206118 @default.
- W2077458217 cites W2062177457 @default.
- W2077458217 cites W2064560552 @default.
- W2077458217 cites W2064632966 @default.
- W2077458217 cites W2064750581 @default.
- W2077458217 cites W2077261245 @default.
- W2077458217 cites W2080157706 @default.
- W2077458217 cites W2081636878 @default.
- W2077458217 cites W2085522577 @default.
- W2077458217 cites W2090640831 @default.
- W2077458217 cites W2090725078 @default.
- W2077458217 cites W2092280582 @default.
- W2077458217 cites W2093767384 @default.
- W2077458217 cites W2095886509 @default.
- W2077458217 cites W2105089251 @default.
- W2077458217 cites W2109562835 @default.
- W2077458217 cites W2109606373 @default.
- W2077458217 cites W2110076945 @default.
- W2077458217 cites W2113345160 @default.
- W2077458217 cites W2116577997 @default.
- W2077458217 cites W2120770718 @default.
- W2077458217 cites W2124727568 @default.
- W2077458217 cites W2134400574 @default.
- W2077458217 cites W2138899586 @default.
- W2077458217 cites W2143832820 @default.
- W2077458217 cites W2157321686 @default.
- W2077458217 cites W2313949965 @default.
- W2077458217 cites W2413730651 @default.
- W2077458217 cites W2491676022 @default.
- W2077458217 cites W4237715311 @default.
- W2077458217 cites W4296041747 @default.
- W2077458217 cites W9924976 @default.
- W2077458217 doi "https://doi.org/10.1038/nprot.2015.008" @default.
- W2077458217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31168086" @default.
- W2077458217 hasPublicationYear "2015" @default.
- W2077458217 type Work @default.
- W2077458217 sameAs 2077458217 @default.
- W2077458217 citedByCount "232" @default.
- W2077458217 countsByYear W20774582172015 @default.
- W2077458217 countsByYear W20774582172016 @default.
- W2077458217 countsByYear W20774582172017 @default.
- W2077458217 countsByYear W20774582172018 @default.
- W2077458217 countsByYear W20774582172019 @default.
- W2077458217 countsByYear W20774582172020 @default.
- W2077458217 countsByYear W20774582172021 @default.
- W2077458217 countsByYear W20774582172022 @default.
- W2077458217 countsByYear W20774582172023 @default.
- W2077458217 crossrefType "journal-article" @default.
- W2077458217 hasAuthorship W2077458217A5021463634 @default.
- W2077458217 hasAuthorship W2077458217A5048992309 @default.
- W2077458217 hasAuthorship W2077458217A5053552375 @default.
- W2077458217 hasAuthorship W2077458217A5062345597 @default.
- W2077458217 hasAuthorship W2077458217A5062928139 @default.
- W2077458217 hasAuthorship W2077458217A5087549132 @default.
- W2077458217 hasBestOaLocation W20774582172 @default.
- W2077458217 hasConcept C119857082 @default.
- W2077458217 hasConcept C124101348 @default.
- W2077458217 hasConcept C151304367 @default.
- W2077458217 hasConcept C153180895 @default.
- W2077458217 hasConcept C154945302 @default.
- W2077458217 hasConcept C159078339 @default.
- W2077458217 hasConcept C161584116 @default.
- W2077458217 hasConcept C185592680 @default.
- W2077458217 hasConcept C186060115 @default.
- W2077458217 hasConcept C198531522 @default.
- W2077458217 hasConcept C199360897 @default.
- W2077458217 hasConcept C22354355 @default.