FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077460064> ?p ?o ?g. }

• W2077460064 endingPage "951" @default.
• W2077460064 startingPage "943" @default.
• W2077460064 abstract "Summary. Background: Various types of laminin (LN) are ubiquitous components of basement membrane and exposed to blood upon localized damage of vascular endothelial cells. Fibronectin is a plasma protein that is insolubilized into fibrils in a regulated fashion by, for example, lysophosphatidic acid (LPA)-stimulated fibroblasts or platelets spread on supportive adhesive ligands. Objective: To study assembly of plasma fibronectin by LPA-activated platelets adherent to LN-111 via α6β1 integrin. Results: Platelets adherent to LN-111-bound plasma fibronectin or its N-terminal 70 kD fragment in fibrillar arrays at the periphery of spread platelets under static but not shear conditions. Formation of fibronectin arrays under static conditions was inhibited by co-incubation with the N-terminal 70 kD fragment or with a 49-amino acid peptide that binds to the N-terminal region of fibronectin. Approximately 7000 fibronectin dimers bound per adherent platelet with a Kd of 50 nm. Bound 70 kD fragment was readily solubilized with deoxycholate (DOC), whereas bound fibronectin became progressively insoluble. Bound 70 kD fragment became resistant to DOC extraction after treatment with a cell-impermeable, reducible crosslinker. Crosslinked 70 kD fragment was found in a high molecular weight complex. As with fibroblasts, signaling molecules modulating actin cytoskeletal organization controlled expression of binding sites for the N-terminal 70 kD region of fibronectin on adherent platelets. Conclusions: These results indicate that platelets adherent to LN-111 via α6β1 support subsequent assembly of fibronectin, but possibly only under conditions of intermittent or stagnant blood flow." @default.
• W2077460064 created "2016-06-24" @default.
• W2077460064 creator A5037893640 @default.
• W2077460064 creator A5055598414 @default.
• W2077460064 date "2006-05-01" @default.
• W2077460064 modified "2023-09-30" @default.
• W2077460064 title "Characterization of fibronectin assembly by platelets adherent to adsorbed laminin‐111" @default.
• W2077460064 cites W1483633222 @default.
• W2077460064 cites W1503632404 @default.
• W2077460064 cites W1506082716 @default.
• W2077460064 cites W1574694993 @default.
• W2077460064 cites W1586370846 @default.
• W2077460064 cites W1587369907 @default.
• W2077460064 cites W1628719417 @default.
• W2077460064 cites W169704349 @default.
• W2077460064 cites W1924777753 @default.
• W2077460064 cites W1967238923 @default.
• W2077460064 cites W1972934977 @default.
• W2077460064 cites W1978991202 @default.
• W2077460064 cites W1979284177 @default.
• W2077460064 cites W1981827240 @default.
• W2077460064 cites W1986574665 @default.
• W2077460064 cites W1994277288 @default.
• W2077460064 cites W2000201832 @default.
• W2077460064 cites W2010090837 @default.
• W2077460064 cites W2011188133 @default.
• W2077460064 cites W2014473242 @default.
• W2077460064 cites W2023989365 @default.
• W2077460064 cites W2024373128 @default.
• W2077460064 cites W2031935322 @default.
• W2077460064 cites W2036691875 @default.
• W2077460064 cites W2038445932 @default.
• W2077460064 cites W2039881470 @default.
• W2077460064 cites W2045032642 @default.
• W2077460064 cites W2046499889 @default.
• W2077460064 cites W2049451860 @default.
• W2077460064 cites W2063558296 @default.
• W2077460064 cites W2079422646 @default.
• W2077460064 cites W2083216138 @default.
• W2077460064 cites W2085096465 @default.
• W2077460064 cites W2089747862 @default.
• W2077460064 cites W2091407743 @default.
• W2077460064 cites W2131387486 @default.
• W2077460064 cites W2135888012 @default.
• W2077460064 cites W2143764756 @default.
• W2077460064 cites W2146376600 @default.
• W2077460064 cites W2210783467 @default.
• W2077460064 cites W2405525690 @default.
• W2077460064 cites W2417417329 @default.
• W2077460064 cites W4246718493 @default.
• W2077460064 doi "https://doi.org/10.1111/j.1538-7836.2006.01862.x" @default.
• W2077460064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16689739" @default.
• W2077460064 hasPublicationYear "2006" @default.
• W2077460064 type Work @default.
• W2077460064 sameAs 2077460064 @default.
• W2077460064 citedByCount "26" @default.
• W2077460064 countsByYear W20774600642012 @default.
• W2077460064 countsByYear W20774600642013 @default.
• W2077460064 countsByYear W20774600642014 @default.
• W2077460064 countsByYear W20774600642015 @default.
• W2077460064 countsByYear W20774600642016 @default.
• W2077460064 countsByYear W20774600642018 @default.
• W2077460064 countsByYear W20774600642020 @default.
• W2077460064 countsByYear W20774600642022 @default.
• W2077460064 countsByYear W20774600642023 @default.
• W2077460064 crossrefType "journal-article" @default.
• W2077460064 hasAuthorship W2077460064A5037893640 @default.
• W2077460064 hasAuthorship W2077460064A5055598414 @default.
• W2077460064 hasConcept C12554922 @default.
• W2077460064 hasConcept C1491633281 @default.
• W2077460064 hasConcept C153911025 @default.
• W2077460064 hasConcept C185592680 @default.
• W2077460064 hasConcept C189165786 @default.
• W2077460064 hasConcept C195687474 @default.
• W2077460064 hasConcept C203014093 @default.
• W2077460064 hasConcept C2776193487 @default.
• W2077460064 hasConcept C2779814568 @default.
• W2077460064 hasConcept C2908543132 @default.
• W2077460064 hasConcept C3018697912 @default.
• W2077460064 hasConcept C55493867 @default.
• W2077460064 hasConcept C86492073 @default.
• W2077460064 hasConcept C86803240 @default.
• W2077460064 hasConcept C89560881 @default.
• W2077460064 hasConcept C95444343 @default.
• W2077460064 hasConceptScore W2077460064C12554922 @default.
• W2077460064 hasConceptScore W2077460064C1491633281 @default.
• W2077460064 hasConceptScore W2077460064C153911025 @default.
• W2077460064 hasConceptScore W2077460064C185592680 @default.
• W2077460064 hasConceptScore W2077460064C189165786 @default.
• W2077460064 hasConceptScore W2077460064C195687474 @default.
• W2077460064 hasConceptScore W2077460064C203014093 @default.
• W2077460064 hasConceptScore W2077460064C2776193487 @default.
• W2077460064 hasConceptScore W2077460064C2779814568 @default.
• W2077460064 hasConceptScore W2077460064C2908543132 @default.
• W2077460064 hasConceptScore W2077460064C3018697912 @default.
• W2077460064 hasConceptScore W2077460064C55493867 @default.
• W2077460064 hasConceptScore W2077460064C86492073 @default.
• W2077460064 hasConceptScore W2077460064C86803240 @default.

• next