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• W2077465551 abstract "Purpose The aim of this study was to demonstrate the feasibility of a custom‐made phased‐array microcoil within a 400 MH z animal system for the morphological characterization of human skin tissue in correlation with histopathology. Materials and methods A dedicated 7‐channel microcoil‐based MR detector arranged in a phased‐array geometry was developed to combine the advantages of both a large field of view and a high signal‐to‐noise ratio. Standard gradient echo sequences were adapted for the characterization of skin morphology ex vivo . Results In this study, the feasibility of using this type of microdetector, combined with specially manufactured sample holders, to achieve high‐resolution MR images of fresh and formalin‐fixed, normal and hidradenitis suppurativa diseased skin was successfully demonstrated. The setup presented in this work allows reliable acquisitions of high‐resolution images with in‐plane resolution up to 25 × 25 μm², and 100 μm in the orthogonal direction, thereby allowing the differentiation of typical layers of the skin, sebaceous glands and hair follicle. Conclusion This study demonstrates that MR microscopy on skin biopsies can be applied at low cost on a standard animal MR imaging system. The successful imaging of different skin structures ex vivo is a prerequisite for non‐invasive, in vivo application of skin MR microscopy for accurate complementary disease diagnosis in dermatology." @default.
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• W2077465551 date "2014-07-26" @default.
• W2077465551 modified "2023-09-25" @default.
• W2077465551 title "Phased-array of microcoils allows MR microscopy of<i>ex vivo</i>human skin samples at 9.4 T" @default.
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• W2077465551 doi "https://doi.org/10.1111/srt.12157" @default.
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