Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077466374> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2077466374 endingPage "BP4" @default.
- W2077466374 startingPage "BP3" @default.
- W2077466374 abstract "Several theories point out the correlation of the anaesthetic potenties of organic molecules with their membrane solubility. It has been shown that alkanols at nerve-blocking concentrations expand biological membranes (Seeman et al., 1969) or disturb order-parameters associated with the lipid (Chin & Goldstein, 1977). The mode of interaction of n-alkanols and lipids is unknown. In the present communication, the interaction of an homologous series of saturated aliphatic alkanols (C1-C13) with dipalmitoyl-dl-α-phosphatidylcholine (DPPC) is studied by a semi-empirical conformational analysis. This technique was developed to calculate the conformation of phospholipids (Brasseur et al., 1981) and other amphiphilic molecules (Brasseur et al., 1983) taking into account the anisotropic conditions of the interface. It takes into account not only the Van der Waals energies but also electrostatic and torsional energies (Brasseur et al., 1982). To simulate the lipid-water interface, the electrostatic energy is calculated as a function of changes in the dielectric constant. The interfacial anisotropy conditions were found to induce several patterns of interactions of n-alkanols with lipids as their hydrocarbon chain length was increased. For n ≤ 3, the g-conformers are the most probable, giving rise to a water soluble structure. These structures interact only with the polar head group of DPPC. For n ≥ 4, only all-trans conformers are obtained giving rise to anisotropic water insoluble molecular structures. According to the n-alkanols hydrocarbon chain length, 3 patterns of interactions were obtained:" @default.
- W2077466374 created "2016-06-24" @default.
- W2077466374 creator A5023233738 @default.
- W2077466374 creator A5050533193 @default.
- W2077466374 creator A5068990419 @default.
- W2077466374 creator A5079413672 @default.
- W2077466374 date "1984-01-01" @default.
- W2077466374 modified "2023-09-26" @default.
- W2077466374 title "Interaction of n-alkanols with dipalmitoylphosphatidylcholine: a semiempirical conformational analysis" @default.
- W2077466374 cites W2023791421 @default.
- W2077466374 cites W2054917853 @default.
- W2077466374 cites W2073308879 @default.
- W2077466374 doi "https://doi.org/10.3109/13813458409071103" @default.
- W2077466374 hasPublicationYear "1984" @default.
- W2077466374 type Work @default.
- W2077466374 sameAs 2077466374 @default.
- W2077466374 citedByCount "0" @default.
- W2077466374 crossrefType "journal-article" @default.
- W2077466374 hasAuthorship W2077466374A5023233738 @default.
- W2077466374 hasAuthorship W2077466374A5050533193 @default.
- W2077466374 hasAuthorship W2077466374A5068990419 @default.
- W2077466374 hasAuthorship W2077466374A5079413672 @default.
- W2077466374 hasConcept C121332964 @default.
- W2077466374 hasConcept C126061179 @default.
- W2077466374 hasConcept C147789679 @default.
- W2077466374 hasConcept C155574463 @default.
- W2077466374 hasConcept C166950319 @default.
- W2077466374 hasConcept C178790620 @default.
- W2077466374 hasConcept C185592680 @default.
- W2077466374 hasConcept C18705241 @default.
- W2077466374 hasConcept C22499117 @default.
- W2077466374 hasConcept C2776330855 @default.
- W2077466374 hasConcept C2776482079 @default.
- W2077466374 hasConcept C2777207669 @default.
- W2077466374 hasConcept C2778918659 @default.
- W2077466374 hasConcept C2781172473 @default.
- W2077466374 hasConcept C2781327020 @default.
- W2077466374 hasConcept C32909587 @default.
- W2077466374 hasConcept C41625074 @default.
- W2077466374 hasConcept C55493867 @default.
- W2077466374 hasConcept C71240020 @default.
- W2077466374 hasConcept C75079739 @default.
- W2077466374 hasConcept C8010536 @default.
- W2077466374 hasConcept C97355855 @default.
- W2077466374 hasConceptScore W2077466374C121332964 @default.
- W2077466374 hasConceptScore W2077466374C126061179 @default.
- W2077466374 hasConceptScore W2077466374C147789679 @default.
- W2077466374 hasConceptScore W2077466374C155574463 @default.
- W2077466374 hasConceptScore W2077466374C166950319 @default.
- W2077466374 hasConceptScore W2077466374C178790620 @default.
- W2077466374 hasConceptScore W2077466374C185592680 @default.
- W2077466374 hasConceptScore W2077466374C18705241 @default.
- W2077466374 hasConceptScore W2077466374C22499117 @default.
- W2077466374 hasConceptScore W2077466374C2776330855 @default.
- W2077466374 hasConceptScore W2077466374C2776482079 @default.
- W2077466374 hasConceptScore W2077466374C2777207669 @default.
- W2077466374 hasConceptScore W2077466374C2778918659 @default.
- W2077466374 hasConceptScore W2077466374C2781172473 @default.
- W2077466374 hasConceptScore W2077466374C2781327020 @default.
- W2077466374 hasConceptScore W2077466374C32909587 @default.
- W2077466374 hasConceptScore W2077466374C41625074 @default.
- W2077466374 hasConceptScore W2077466374C55493867 @default.
- W2077466374 hasConceptScore W2077466374C71240020 @default.
- W2077466374 hasConceptScore W2077466374C75079739 @default.
- W2077466374 hasConceptScore W2077466374C8010536 @default.
- W2077466374 hasConceptScore W2077466374C97355855 @default.
- W2077466374 hasIssue "2" @default.
- W2077466374 hasLocation W20774663741 @default.
- W2077466374 hasOpenAccess W2077466374 @default.
- W2077466374 hasPrimaryLocation W20774663741 @default.
- W2077466374 hasRelatedWork W1016811321 @default.
- W2077466374 hasRelatedWork W1989402518 @default.
- W2077466374 hasRelatedWork W2007892040 @default.
- W2077466374 hasRelatedWork W2017488631 @default.
- W2077466374 hasRelatedWork W2088809444 @default.
- W2077466374 hasRelatedWork W2334087670 @default.
- W2077466374 hasRelatedWork W2345376172 @default.
- W2077466374 hasRelatedWork W4214776592 @default.
- W2077466374 hasRelatedWork W4280531871 @default.
- W2077466374 hasRelatedWork W2078303713 @default.
- W2077466374 hasVolume "92" @default.
- W2077466374 isParatext "false" @default.
- W2077466374 isRetracted "false" @default.
- W2077466374 magId "2077466374" @default.
- W2077466374 workType "article" @default.