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• W2077470614 abstract "You have accessJournal of UrologyProstate Cancer: Localized1 Apr 20131205 AGE STRATIFIED OUTCOMES AFTER PRIMARY HIFU FOR ORGAN LOCALIZED PROSTATE CANCER IN THE SERIE OF 5206 PATIENTS Baco Eduard, Andreas Blana, Berge Viktor, Christian Chaussy, Roman Ganzer, Sebastien Crouzet, Gilles Pasticier, Antonello Paulesu, Cary N. Robertson, Stefan Thueroff, John F. Ward, Rafael Sanchez-Salas, and Albert Gelet Baco EduardBaco Eduard Oslo, Norway More articles by this author , Andreas BlanaAndreas Blana Fuerth, Germany More articles by this author , Berge ViktorBerge Viktor Oslo, Norway More articles by this author , Christian ChaussyChristian Chaussy Regensburg, Germany More articles by this author , Roman GanzerRoman Ganzer Regensburg, Germany More articles by this author , Sebastien CrouzetSebastien Crouzet Lyon, France More articles by this author , Gilles PasticierGilles Pasticier Bordeaux, France More articles by this author , Antonello PaulesuAntonello Paulesu Como, Italy More articles by this author , Cary N. RobertsonCary N. Robertson Durham, NC More articles by this author , Stefan ThueroffStefan Thueroff Munchen, Germany More articles by this author , John F. WardJohn F. Ward Huston, TX More articles by this author , Rafael Sanchez-SalasRafael Sanchez-Salas Paris, France More articles by this author , and Albert GeletAlbert Gelet Lyon, France More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2559AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES High intensity focused ultrasound (HIFU) performed by Ablatherm® has been used as primary treatment of localized prostate cancer since 1993. In the last years, HIFU has been recognized as a therapeutic option in patients over 70 years old with 10 years life expectancy. The objective of this study is to report the biochemical and biopsy outcomes, stratified by age, in patients who have undergone HIFU. METHODS 5206 consecutive patients with cT1-T3 prostate cancer treated by HIFU Ablatherm® (EDAP-TMS, Lyon, France), 16 European HIFU centers were included. Treatment results, and post treatment morbidity as the bladder outlet obstruction (BOO) or urethra stenosis have been registered in the online Ablatherm® HIFU database, @-Registry. This is a secured on-line database collecting relevant de-identified clinical and technical information for patients treated by HIFU. Patients were stratified by age into two groups: below 70 years (n=2291) and above 70 years (n=2915) and according to D'Amico's 2003 risk group classification. Kaplan-Meier analyses were performed to determine biochemical survival with failure defined according to the 2006 Phoenix definition (nadir+2). Univariable and multivariable Cox analyses were performed to adjust for possible confounding variables (clinical stage, Gleason score, PSA, prostate volume). RESULTS Follow-up time was 3.4 ± 2.9 years. The median PSA nadir: 0.15 ng/ml was reached 14.0 ± 11.5 weeks after HIFU. The negative biopsy rates (<70 yrs / >70yrs) were 70% / 73%, actuarial biochemical disease free survival (BDFS) at 5 years: 84% / 73% low risk, 74% / 65% intermediate risk, 69% / 63% high risk patients. Urinary incontinence rates (GII and GIII) were 4% / 7%. BOO or urethra stenosis rates were 18% / 19 %. CONCLUSIONS HIFU presents positive oncological and functional outcome in patients both below and above 70 years. HIFU treatment appears therefore as a valuable therapeutic option for prostate cancer control independent of age. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e494 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Baco Eduard Oslo, Norway More articles by this author Andreas Blana Fuerth, Germany More articles by this author Berge Viktor Oslo, Norway More articles by this author Christian Chaussy Regensburg, Germany More articles by this author Roman Ganzer Regensburg, Germany More articles by this author Sebastien Crouzet Lyon, France More articles by this author Gilles Pasticier Bordeaux, France More articles by this author Antonello Paulesu Como, Italy More articles by this author Cary N. Robertson Durham, NC More articles by this author Stefan Thueroff Munchen, Germany More articles by this author John F. Ward Huston, TX More articles by this author Rafael Sanchez-Salas Paris, France More articles by this author Albert Gelet Lyon, France More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ..." @default.
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• W2077470614 title "1205 AGE STRATIFIED OUTCOMES AFTER PRIMARY HIFU FOR ORGAN LOCALIZED PROSTATE CANCER IN THE SERIE OF 5206 PATIENTS" @default.
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