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• W2077475587 abstract "A series of novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors was prepared via treatment of various diaryl amides with tetrachlorosilane/sodium azide. All compounds were tested in cyclooxygenase (COX) assays in vitro to determine COX-1 and COX-2 inhibitory potency and selectivity. Tetrazoles contained a methylsulfonyl or sulfonamide group as COX-2 pharmacophore displayed only low inhibitory potency towards COX-2. Most potent compounds showed IC50 values of 6 and 7 μM for COX-2. All compounds showed IC50 values greater 100 μM for COX-1 inhibition." @default.
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• W2077475587 date "2012-03-01" @default.
• W2077475587 modified "2023-10-11" @default.
• W2077475587 title "Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors" @default.
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• W2077475587 doi "https://doi.org/10.1016/j.bmcl.2012.01.093" @default.
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