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- W2077480963 abstract "The fruit of Schisandra chinensis, a woody liana, has been usedfor centuries in traditional Chinese medicine. The fruit isprescribed for the treatment of viral and chemically inducedhepatitis in China. Extracts of Schisandra chinensis havedemonstrated hepatoprotective and cardioprotective activities,which can be potentially connected with ability to reduceoxidative stress. The aim of our study was to characterisecompounds, which correspond for antioxidant activity ofSchisandra chinensis. The petroleum ether extract of seeds ofSchisandra chinensis showed scavenging activity against thefree stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH. Thepetroleum ether extract was extracted with methanol and themethanolic extract was further chromatographed on silica gelcolumn with petroleum ether, benzene, diethyl ether and ethanolas a mobile phase. The most active fractions eluted withbenzene were further fractioned on silica gel column andSephadex LH-20 column and by semi-preparative RP-HPLC. Bioassayguided fractionation led to the isolation of dibenzylbutanelignan meso-dihydroguaiaretic acid anddibenzo[a,c]cyclooctadiene lignans schisanhenol and gomisin J.All active lignans containing one or two phenolic hydroxylsbelong to minor lignan constituents of Schisandra. Togetherwith the active lignans, nine dibenzocyclooctadiene lignanswere isolated, namely, schizandrin, deoxyschizandrin,gamma-schizandrin, gomisin A, gomisin N, tigloylgomisin H,angeloylgomisin H, tigloylgomisin P and wuweizisu C. Thelignans were identified by spectroscopic methods (1H and 13CNMR, MS)." @default.
- W2077480963 created "2016-06-24" @default.
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- W2077480963 date "2008-07-01" @default.
- W2077480963 modified "2023-09-26" @default.
- W2077480963 title "Antioxidant lignans from petroleum ether extract of Schisandra chinensis" @default.
- W2077480963 doi "https://doi.org/10.1055/s-0028-1084052" @default.
- W2077480963 hasPublicationYear "2008" @default.
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