FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077483764> ?p ?o ?g. }

• W2077483764 endingPage "203" @default.
• W2077483764 startingPage "171" @default.
• W2077483764 abstract "A wide diversity of animal models has been used to examine antidepressant activity. These range from relatively simple models sensitive to acute treatment, to highly sophisticated models that reputedly model some aspect of depressive illness and which yield a positive response to prolonged, chronic, drug treatment. In recent years antidepressant drug research has focused on the search for antidepressant therapy that has a more rapid onset of action. To be relevant, therefore, animal models must measure the time course of drug action. This review examines the claims of animal models to be sensitive to chronic drug treatment and considers their relevance. First, the review addresses the criteria necessary to examine the validity of animal models of depressive illness. Second, those animal models sensitive to chronic antidepressant treatment are reviewed with respect to their validity as animal models of either depressive illness and / or antidepressant activity. In particular, the development and utility of two ethologically-relevant animal models, the resident-intruder and social hierarchy paradigms, are described in detail. These models of rodent social and agonistic behaviour demonstrate that acute and chronic treatment with antidepressant drugs (regardless of their acute pharmacological activity) induce diametrically opposite changes in rodent agonistic behaviour. It is argued that the common ability of chronic treatment to increase rodent aggression (which in turn results in increased hierarchical status in closed social groups) most likely reflects the increased assertiveness and associated externalization of emotions expressed during recovery from depressive illness. Finally, findings that relate observed behavioural changes to underlying neurochemical changes are briefly reviewed. Keywords: antidepressant treatment, animal models of depression, chronic drug treatment, ethology, agonistic behaviour, social hierarchy, resident-intruder" @default.
• W2077483764 created "2016-06-24" @default.
• W2077483764 creator A5004148008 @default.
• W2077483764 creator A5015702645 @default.
• W2077483764 date "2005-01-01" @default.
• W2077483764 modified "2023-09-27" @default.
• W2077483764 title "Animal Models of Depressive Illness: The Importance of Chronic Drug Treatment" @default.
• W2077483764 cites W116114088 @default.
• W2077483764 cites W137993874 @default.
• W2077483764 cites W1482632432 @default.
• W2077483764 cites W1508825618 @default.
• W2077483764 cites W1530003357 @default.
• W2077483764 cites W1534364926 @default.
• W2077483764 cites W1561644443 @default.
• W2077483764 cites W1562049887 @default.
• W2077483764 cites W1578600378 @default.
• W2077483764 cites W1749789373 @default.
• W2077483764 cites W1790836 @default.
• W2077483764 cites W183627304 @default.
• W2077483764 cites W1865353504 @default.
• W2077483764 cites W190339498 @default.
• W2077483764 cites W1963781127 @default.
• W2077483764 cites W1963803319 @default.
• W2077483764 cites W1965027767 @default.
• W2077483764 cites W1965454331 @default.
• W2077483764 cites W1965512378 @default.
• W2077483764 cites W1968439188 @default.
• W2077483764 cites W1969143567 @default.
• W2077483764 cites W1969466593 @default.
• W2077483764 cites W1969480394 @default.
• W2077483764 cites W1970118775 @default.
• W2077483764 cites W1970372953 @default.
• W2077483764 cites W1970945239 @default.
• W2077483764 cites W1971696606 @default.
• W2077483764 cites W1971711780 @default.
• W2077483764 cites W1972598163 @default.
• W2077483764 cites W1974933125 @default.
• W2077483764 cites W1975207189 @default.
• W2077483764 cites W1975385070 @default.
• W2077483764 cites W1975582059 @default.
• W2077483764 cites W1975875551 @default.
• W2077483764 cites W1977752334 @default.
• W2077483764 cites W1979344515 @default.
• W2077483764 cites W1979355353 @default.
• W2077483764 cites W1979635480 @default.
• W2077483764 cites W1980012680 @default.
• W2077483764 cites W1981127102 @default.
• W2077483764 cites W1981518746 @default.
• W2077483764 cites W1982335931 @default.
• W2077483764 cites W1983120517 @default.
• W2077483764 cites W1983544699 @default.
• W2077483764 cites W1984960813 @default.
• W2077483764 cites W1985991621 @default.
• W2077483764 cites W1986571862 @default.
• W2077483764 cites W1987491785 @default.
• W2077483764 cites W1988966795 @default.
• W2077483764 cites W1989446622 @default.
• W2077483764 cites W1990057336 @default.
• W2077483764 cites W1990135901 @default.
• W2077483764 cites W1990613148 @default.
• W2077483764 cites W1990678641 @default.
• W2077483764 cites W1990958610 @default.
• W2077483764 cites W1991201649 @default.
• W2077483764 cites W1991452929 @default.
• W2077483764 cites W1991527095 @default.
• W2077483764 cites W1994096357 @default.
• W2077483764 cites W1994645365 @default.
• W2077483764 cites W1994702289 @default.
• W2077483764 cites W1996888878 @default.
• W2077483764 cites W1997440941 @default.
• W2077483764 cites W1998580054 @default.
• W2077483764 cites W1998904957 @default.
• W2077483764 cites W1999721747 @default.
• W2077483764 cites W2000610098 @default.
• W2077483764 cites W2003209512 @default.
• W2077483764 cites W2004118951 @default.
• W2077483764 cites W2005128569 @default.
• W2077483764 cites W2006187729 @default.
• W2077483764 cites W2009230960 @default.
• W2077483764 cites W2009463091 @default.
• W2077483764 cites W2010078670 @default.
• W2077483764 cites W2012112814 @default.
• W2077483764 cites W2012861818 @default.
• W2077483764 cites W2013626321 @default.
• W2077483764 cites W2014444735 @default.
• W2077483764 cites W2015351890 @default.
• W2077483764 cites W2015933168 @default.
• W2077483764 cites W2016238758 @default.
• W2077483764 cites W2018076297 @default.
• W2077483764 cites W2019740418 @default.
• W2077483764 cites W2020011498 @default.
• W2077483764 cites W2020568349 @default.
• W2077483764 cites W2022502205 @default.
• W2077483764 cites W2024493419 @default.
• W2077483764 cites W2026050874 @default.
• W2077483764 cites W2026854671 @default.
• W2077483764 cites W2028880348 @default.
• W2077483764 cites W2028909517 @default.

• next