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- W2077489462 abstract "Concern has been expressed about the efficacy of Varicella-Zoster Immune Globulin (VZIG) given intramuscularly (IM) to high risk individuals exposed to varicella. Perceived decreased efficacy may be due to more intensive chemotherapy and/or decreased potency of VZIG. Varicella-zoster antibody titers (VZAT) were determined by enzyme-linked immunosorbent assay for 21 normal adults and 23 susceptibles; the means and standard deviations were 0.600 ± 0.310, and 0.020 ± 0.0153 respectively. The seronegative range was defined as the mean for susceptibles +3 SD, ≤0.066. The peak mean VZAT in 7 seronegative VZIG recipients was 0.123 and, at 4-8 weeks, only 0.066. Thus, the peak VZAT provides minimal levels of antibody. Moreover, a second exposure following the usual incubation period would require an additional dose of VZIG. In contrast, 11 seronegative patients who received intravenous transfusions of platelets, white blood cells in plasma, or plasma alone had peak mean VZAT of 0.310. For 9/9 patients the duration of seropositivity lasted 4 weeks and for 2/5 as long as 12 weeks. Much higher peak titers of antibody were achieved than by IM VZIG (p 0.01 > 0.02) which might further reduce morbidity. Larger volumes of antibody could be given IV than IM, there is less pain, and thrombocytopenia would not be a deterent. Development of an IV VZIG preparation would appear to have a greater likelihood of reducing morbidity from varicella." @default.
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- W2077489462 date "1985-04-01" @default.
- W2077489462 modified "2023-10-17" @default.
- W2077489462 title "946 A REASSESSMENT OF PASSIVE IMMUNIZATION AGAINST VARICELLA" @default.
- W2077489462 doi "https://doi.org/10.1203/00006450-198504000-00976" @default.
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