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• W2077492033 abstract "The tumor microenvironment is an important aspect of cancer biology that contributes to tumor initiation, tumor progression and responses to therapy. The composition and characteristics of the tumor microenvironment vary widely and are important in determining the anti-tumor immune response. Successful immunization requires activation of both innate and adaptive immunity. Generally, immune system is compromised in patients with cancer due to immune suppression, loss of tumor antigen expression and dysfunction of antigen presenting cells (APC). Thus, therapeutic immunization leading to cancer regression remains a significant challenge. Certain cells of the immune system, including dendritic cells (DCs) and gamma delta (γδ) T cells are capable of driving potent anti-tumor responses. The property of MHC-unrestricted cytotoxicity, high potential of cytokine release, tissue tropism and early activation in infections and malignant disease makes γδ T cells as an emerging candidate for immunotherapy. Various strategies are being developed to enhance anti-tumor immune responses of γδ T cells and DCs one of them is the use of novel adjuvants like toll like receptors (TLR) agonists, which enhance γδ T cell function directly or through DC activation, which has ability to prime γδ T cells. TLR agonists are being used clinically either alone or in combination with tumor antigens and has shown initial success in both enhancing immune responses and eliciting anti-tumor activity. TLR activated γδ T cells and DCs nurture each other's activation. This provides a potent base for first line of defense and manipulation of the adaptive response against pathogens and cancer. The available data provides a strong rationale for initiating combinatorial therapy for the treatment of diseases and this review will summarize the application of adjuvants (TLRs) for boosting immune response of γδ T cells to treat cancer and infectious diseases and their use in combinatorial therapy." @default.
• W2077492033 created "2016-06-24" @default.
• W2077492033 creator A5026412878 @default.
• W2077492033 creator A5042396485 @default.
• W2077492033 creator A5065683003 @default.
• W2077492033 date "2014-07-31" @default.
• W2077492033 modified "2023-10-10" @default.
• W2077492033 title "Insights into the Relationship between Toll Like Receptors and Gamma Delta T Cell Responses" @default.
• W2077492033 cites W1482602608 @default.
• W2077492033 cites W1483162601 @default.
• W2077492033 cites W1483242994 @default.
• W2077492033 cites W1484643071 @default.
• W2077492033 cites W1492322782 @default.
• W2077492033 cites W1495069464 @default.
• W2077492033 cites W1499138178 @default.
• W2077492033 cites W1500424702 @default.
• W2077492033 cites W1505219365 @default.
• W2077492033 cites W1509093479 @default.
• W2077492033 cites W1519843522 @default.
• W2077492033 cites W1524162807 @default.
• W2077492033 cites W1525957142 @default.
• W2077492033 cites W1528231659 @default.
• W2077492033 cites W1535243328 @default.
• W2077492033 cites W1546142467 @default.
• W2077492033 cites W1568165627 @default.
• W2077492033 cites W1601232563 @default.
• W2077492033 cites W1602194841 @default.
• W2077492033 cites W1613634425 @default.
• W2077492033 cites W1655860314 @default.
• W2077492033 cites W1660648079 @default.
• W2077492033 cites W1764179577 @default.
• W2077492033 cites W1770811198 @default.
• W2077492033 cites W1832248617 @default.
• W2077492033 cites W1852860294 @default.
• W2077492033 cites W1866402598 @default.
• W2077492033 cites W1885581908 @default.
• W2077492033 cites W1894405407 @default.
• W2077492033 cites W1897399348 @default.
• W2077492033 cites W1906543170 @default.
• W2077492033 cites W1915217100 @default.
• W2077492033 cites W1965433818 @default.
• W2077492033 cites W1966772446 @default.
• W2077492033 cites W1969501356 @default.
• W2077492033 cites W1971761379 @default.
• W2077492033 cites W1973659410 @default.
• W2077492033 cites W1974631787 @default.
• W2077492033 cites W1975275391 @default.
• W2077492033 cites W1976158536 @default.
• W2077492033 cites W1982662898 @default.
• W2077492033 cites W1984814243 @default.
• W2077492033 cites W1985766571 @default.
• W2077492033 cites W1989656760 @default.
• W2077492033 cites W1990777782 @default.
• W2077492033 cites W1991125871 @default.
• W2077492033 cites W1994624777 @default.
• W2077492033 cites W1995586746 @default.
• W2077492033 cites W1995744610 @default.
• W2077492033 cites W1995930566 @default.
• W2077492033 cites W1998143989 @default.
• W2077492033 cites W2000230310 @default.
• W2077492033 cites W2004828548 @default.
• W2077492033 cites W2007476974 @default.
• W2077492033 cites W2009521410 @default.
• W2077492033 cites W2010623178 @default.
• W2077492033 cites W2012720624 @default.
• W2077492033 cites W2013601771 @default.
• W2077492033 cites W2014012740 @default.
• W2077492033 cites W2014913358 @default.
• W2077492033 cites W2017453418 @default.
• W2077492033 cites W2018587471 @default.
• W2077492033 cites W2019985217 @default.
• W2077492033 cites W2021984884 @default.
• W2077492033 cites W2022050925 @default.
• W2077492033 cites W2022221965 @default.
• W2077492033 cites W2023403245 @default.
• W2077492033 cites W2024404066 @default.
• W2077492033 cites W2025859745 @default.
• W2077492033 cites W2028584099 @default.
• W2077492033 cites W2030611349 @default.
• W2077492033 cites W2030635490 @default.
• W2077492033 cites W2033081825 @default.
• W2077492033 cites W2033144954 @default.
• W2077492033 cites W2033415145 @default.
• W2077492033 cites W2035809809 @default.
• W2077492033 cites W2037168313 @default.
• W2077492033 cites W2039959261 @default.
• W2077492033 cites W2040154148 @default.
• W2077492033 cites W2043577628 @default.
• W2077492033 cites W2049197565 @default.
• W2077492033 cites W2049449911 @default.
• W2077492033 cites W2051476172 @default.
• W2077492033 cites W2052012061 @default.
• W2077492033 cites W2052160940 @default.
• W2077492033 cites W2056204715 @default.
• W2077492033 cites W2060716894 @default.
• W2077492033 cites W2061203855 @default.
• W2077492033 cites W2061979469 @default.
• W2077492033 cites W2063120378 @default.
• W2077492033 cites W2063521817 @default.
• W2077492033 cites W2065186557 @default.

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