FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077492083> ?p ?o ?g. }

• W2077492083 endingPage "209" @default.
• W2077492083 startingPage "199" @default.
• W2077492083 abstract "We investigated the mechanisms by which insulin-like growth factor I (IGF-I) acts to increase the number of oligodendrocytes that develop in cultures of cells explanted from perinatal rat cerebrum. Fluorescence-activated cell sorting was used to isolate bipotential A2B5-positive oligodendrocyte-type 2 astrocyte (O-2A) progenitor cells, which were then inoculated as single cells into microculture wells containing feeder layers of X-irradiated type 1 astrocytes. Addition of 100 ng/ml IGF-I to the culture medium increased the growth rate and the ultimate size reached by the resulting clones during the 18-day experimental period. Moreover, 75-80% of the cells in the IGF-I-treated clones differentiated into galactocerebroside (GC)-positive oligodendrocytes, whereas only 25-30% became oligodendrocytes in the absence of IGF-I. IGF-I did not increase the number of type 2 astrocytes that developed in the clones. IGF-I appeared to have the greatest effect on growth and differentiation at a stage when the majority of the cells in the clones were at an intermediate stage of development, characterized by the expression of A2B5 and O4 glycolipid antigens but not GC. Analysis of the effects of IGF-I on O4-positive, GC-negative intermediate precursor cells revealed a two to fivefold increase in the number of cells that incorporated 3H-thymidine into their DNA during a 5-h pulse. Moreover, IGF-I increased the number of cell sorter-purified O4-positive cells that developed into oligodendrocytes 4-8 days later. Therefore, IGF-I acts in two different ways to promote oligodendrocyte development: It promotes proliferation of precursor cells in the O-2A lineage, and it induces precursors to become committed to develop into oligodendrocytes." @default.
• W2077492083 created "2016-06-24" @default.
• W2077492083 creator A5009286719 @default.
• W2077492083 creator A5012816784 @default.
• W2077492083 date "1988-10-01" @default.
• W2077492083 modified "2023-10-16" @default.
• W2077492083 title "Insulin‐like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro" @default.
• W2077492083 cites W1501040940 @default.
• W2077492083 cites W1811206105 @default.
• W2077492083 cites W1829859617 @default.
• W2077492083 cites W1939198520 @default.
• W2077492083 cites W1972524334 @default.
• W2077492083 cites W1974967725 @default.
• W2077492083 cites W1977994351 @default.
• W2077492083 cites W1979286083 @default.
• W2077492083 cites W1987885030 @default.
• W2077492083 cites W2004660705 @default.
• W2077492083 cites W2005272267 @default.
• W2077492083 cites W2007434276 @default.
• W2077492083 cites W2012639883 @default.
• W2077492083 cites W2027983444 @default.
• W2077492083 cites W2036567890 @default.
• W2077492083 cites W2050601632 @default.
• W2077492083 cites W2055451031 @default.
• W2077492083 cites W2074558188 @default.
• W2077492083 cites W2078326745 @default.
• W2077492083 cites W2096428903 @default.
• W2077492083 cites W2126907710 @default.
• W2077492083 cites W2145481755 @default.
• W2077492083 cites W2221064544 @default.
• W2077492083 doi "https://doi.org/10.1002/jnr.490210212" @default.
• W2077492083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3216421" @default.
• W2077492083 hasPublicationYear "1988" @default.
• W2077492083 type Work @default.
• W2077492083 sameAs 2077492083 @default.
• W2077492083 citedByCount "347" @default.
• W2077492083 countsByYear W20774920832012 @default.
• W2077492083 countsByYear W20774920832013 @default.
• W2077492083 countsByYear W20774920832014 @default.
• W2077492083 countsByYear W20774920832015 @default.
• W2077492083 countsByYear W20774920832016 @default.
• W2077492083 countsByYear W20774920832017 @default.
• W2077492083 countsByYear W20774920832018 @default.
• W2077492083 countsByYear W20774920832019 @default.
• W2077492083 countsByYear W20774920832020 @default.
• W2077492083 countsByYear W20774920832021 @default.
• W2077492083 countsByYear W20774920832022 @default.
• W2077492083 countsByYear W20774920832023 @default.
• W2077492083 crossrefType "journal-article" @default.
• W2077492083 hasAuthorship W2077492083A5009286719 @default.
• W2077492083 hasAuthorship W2077492083A5012816784 @default.
• W2077492083 hasConcept C124964019 @default.
• W2077492083 hasConcept C134018914 @default.
• W2077492083 hasConcept C153911025 @default.
• W2077492083 hasConcept C170493617 @default.
• W2077492083 hasConcept C201750760 @default.
• W2077492083 hasConcept C202751555 @default.
• W2077492083 hasConcept C2775960820 @default.
• W2077492083 hasConcept C2776985911 @default.
• W2077492083 hasConcept C2777108182 @default.
• W2077492083 hasConcept C2777542381 @default.
• W2077492083 hasConcept C2778609137 @default.
• W2077492083 hasConcept C2778630268 @default.
• W2077492083 hasConcept C2780689927 @default.
• W2077492083 hasConcept C2781017270 @default.
• W2077492083 hasConcept C28328180 @default.
• W2077492083 hasConcept C49377226 @default.
• W2077492083 hasConcept C529278444 @default.
• W2077492083 hasConcept C54355233 @default.
• W2077492083 hasConcept C55493867 @default.
• W2077492083 hasConcept C62112901 @default.
• W2077492083 hasConcept C81885089 @default.
• W2077492083 hasConcept C86803240 @default.
• W2077492083 hasConcept C95444343 @default.
• W2077492083 hasConceptScore W2077492083C124964019 @default.
• W2077492083 hasConceptScore W2077492083C134018914 @default.
• W2077492083 hasConceptScore W2077492083C153911025 @default.
• W2077492083 hasConceptScore W2077492083C170493617 @default.
• W2077492083 hasConceptScore W2077492083C201750760 @default.
• W2077492083 hasConceptScore W2077492083C202751555 @default.
• W2077492083 hasConceptScore W2077492083C2775960820 @default.
• W2077492083 hasConceptScore W2077492083C2776985911 @default.
• W2077492083 hasConceptScore W2077492083C2777108182 @default.
• W2077492083 hasConceptScore W2077492083C2777542381 @default.
• W2077492083 hasConceptScore W2077492083C2778609137 @default.
• W2077492083 hasConceptScore W2077492083C2778630268 @default.
• W2077492083 hasConceptScore W2077492083C2780689927 @default.
• W2077492083 hasConceptScore W2077492083C2781017270 @default.
• W2077492083 hasConceptScore W2077492083C28328180 @default.
• W2077492083 hasConceptScore W2077492083C49377226 @default.
• W2077492083 hasConceptScore W2077492083C529278444 @default.
• W2077492083 hasConceptScore W2077492083C54355233 @default.
• W2077492083 hasConceptScore W2077492083C55493867 @default.
• W2077492083 hasConceptScore W2077492083C62112901 @default.
• W2077492083 hasConceptScore W2077492083C81885089 @default.
• W2077492083 hasConceptScore W2077492083C86803240 @default.
• W2077492083 hasConceptScore W2077492083C95444343 @default.
• W2077492083 hasIssue "2-4" @default.

• next