FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077496215> ?p ?o ?g. }

• W2077496215 endingPage "2526" @default.
• W2077496215 startingPage "2518" @default.
• W2077496215 abstract "Several CD4 mimics have been reported as HIV-1 entry inhibitors that can intervene in the interaction between a viral envelope glycoprotein gp120 and a cell surface protein CD4. Our previous SAR studies led to a finding of a highly potent analogue 3 with bulky hydrophobic groups on a piperidine moiety. In the present study, the aromatic ring of 3 was modified systematically in an attempt to improve its antiviral activity and CD4 mimicry which induces the conformational changes in gp120 that can render the envelope more sensitive to neutralizing antibodies. Biological assays of the synthetic compounds revealed that the introduction of a fluorine group as a meta-substituent of the aromatic ring caused an increase of anti-HIV activity and an enhancement of a CD4 mimicry, and led to a novel compound 13a that showed twice as potent anti-HIV activity compared to 3 and a substantial increase in a CD4 mimicry even at lower concentrations." @default.
• W2077496215 created "2016-06-24" @default.
• W2077496215 creator A5009917377 @default.
• W2077496215 creator A5014453137 @default.
• W2077496215 creator A5018572637 @default.
• W2077496215 creator A5032006477 @default.
• W2077496215 creator A5039430795 @default.
• W2077496215 creator A5048431089 @default.
• W2077496215 creator A5055176225 @default.
• W2077496215 creator A5061066996 @default.
• W2077496215 creator A5069343634 @default.
• W2077496215 creator A5069498173 @default.
• W2077496215 date "2013-05-01" @default.
• W2077496215 modified "2023-09-23" @default.
• W2077496215 title "CD4 mimics as HIV entry inhibitors: Lead optimization studies of the aromatic substituents" @default.
• W2077496215 cites W1967178061 @default.
• W2077496215 cites W1983225937 @default.
• W2077496215 cites W1984625229 @default.
• W2077496215 cites W1992984464 @default.
• W2077496215 cites W2013141399 @default.
• W2077496215 cites W2027738518 @default.
• W2077496215 cites W2039613640 @default.
• W2077496215 cites W2044790939 @default.
• W2077496215 cites W2051775752 @default.
• W2077496215 cites W2072712067 @default.
• W2077496215 cites W2086974099 @default.
• W2077496215 cites W2098781795 @default.
• W2077496215 cites W2107541609 @default.
• W2077496215 cites W2110838631 @default.
• W2077496215 cites W2141666704 @default.
• W2077496215 cites W2147009832 @default.
• W2077496215 cites W2168455946 @default.
• W2077496215 cites W2415905866 @default.
• W2077496215 doi "https://doi.org/10.1016/j.bmc.2013.02.041" @default.
• W2077496215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23535561" @default.
• W2077496215 hasPublicationYear "2013" @default.
• W2077496215 type Work @default.
• W2077496215 sameAs 2077496215 @default.
• W2077496215 citedByCount "34" @default.
• W2077496215 countsByYear W20774962152013 @default.
• W2077496215 countsByYear W20774962152014 @default.
• W2077496215 countsByYear W20774962152015 @default.
• W2077496215 countsByYear W20774962152016 @default.
• W2077496215 countsByYear W20774962152017 @default.
• W2077496215 countsByYear W20774962152018 @default.
• W2077496215 countsByYear W20774962152019 @default.
• W2077496215 countsByYear W20774962152020 @default.
• W2077496215 countsByYear W20774962152021 @default.
• W2077496215 countsByYear W20774962152022 @default.
• W2077496215 countsByYear W20774962152023 @default.
• W2077496215 crossrefType "journal-article" @default.
• W2077496215 hasAuthorship W2077496215A5009917377 @default.
• W2077496215 hasAuthorship W2077496215A5014453137 @default.
• W2077496215 hasAuthorship W2077496215A5018572637 @default.
• W2077496215 hasAuthorship W2077496215A5032006477 @default.
• W2077496215 hasAuthorship W2077496215A5039430795 @default.
• W2077496215 hasAuthorship W2077496215A5048431089 @default.
• W2077496215 hasAuthorship W2077496215A5055176225 @default.
• W2077496215 hasAuthorship W2077496215A5061066996 @default.
• W2077496215 hasAuthorship W2077496215A5069343634 @default.
• W2077496215 hasAuthorship W2077496215A5069498173 @default.
• W2077496215 hasConcept C116073593 @default.
• W2077496215 hasConcept C159654299 @default.
• W2077496215 hasConcept C178790620 @default.
• W2077496215 hasConcept C185592680 @default.
• W2077496215 hasConcept C18903297 @default.
• W2077496215 hasConcept C193042331 @default.
• W2077496215 hasConcept C202751555 @default.
• W2077496215 hasConcept C203014093 @default.
• W2077496215 hasConcept C2776568683 @default.
• W2077496215 hasConcept C2777119779 @default.
• W2077496215 hasConcept C2777752112 @default.
• W2077496215 hasConcept C2778689049 @default.
• W2077496215 hasConcept C2780378348 @default.
• W2077496215 hasConcept C2781462491 @default.
• W2077496215 hasConcept C55493867 @default.
• W2077496215 hasConcept C71240020 @default.
• W2077496215 hasConcept C7863114 @default.
• W2077496215 hasConcept C86803240 @default.
• W2077496215 hasConceptScore W2077496215C116073593 @default.
• W2077496215 hasConceptScore W2077496215C159654299 @default.
• W2077496215 hasConceptScore W2077496215C178790620 @default.
• W2077496215 hasConceptScore W2077496215C185592680 @default.
• W2077496215 hasConceptScore W2077496215C18903297 @default.
• W2077496215 hasConceptScore W2077496215C193042331 @default.
• W2077496215 hasConceptScore W2077496215C202751555 @default.
• W2077496215 hasConceptScore W2077496215C203014093 @default.
• W2077496215 hasConceptScore W2077496215C2776568683 @default.
• W2077496215 hasConceptScore W2077496215C2777119779 @default.
• W2077496215 hasConceptScore W2077496215C2777752112 @default.
• W2077496215 hasConceptScore W2077496215C2778689049 @default.
• W2077496215 hasConceptScore W2077496215C2780378348 @default.
• W2077496215 hasConceptScore W2077496215C2781462491 @default.
• W2077496215 hasConceptScore W2077496215C55493867 @default.
• W2077496215 hasConceptScore W2077496215C71240020 @default.
• W2077496215 hasConceptScore W2077496215C7863114 @default.
• W2077496215 hasConceptScore W2077496215C86803240 @default.
• W2077496215 hasFunder F4320320912 @default.

• next