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- W2077508052 abstract "Abstract The mechanisms of resistance to pyrethroids were studied in a permethrin-selected (147-R) strain of the house fly, Musca domestica L. Approximately 12-fold synergism was obtained with a mixture of (1 R )- trans -permethrin:piperonyl butoxide (1:5) so that the resistance decreased from 97-fold to 22-fold. Tests with the esterase inhibitor S,S,S -tributyl phosphorotrithioate produced very little synergism in either the resistant (R) strain (1.6-fold) or the susceptible (S) strain (1.9-fold). An investigation of the microsomal components revealed that compared to the S strain, the R strain demonstrated twice as much cytochrome P -450 and cytochrome b 5 and double the rate of NADPH-cytochrome c reductase activity. In addition, the rate of p -nitroanisole O -demethylation was found to be six times greater in the R strain. An in vivo accumulation study showed that the R strain displayed a decreased rate of penetration of trans -[ 14 C]permethrin. When treated at equitoxic doses the R strain was found to tolerate 50-fold more internal permethrin than the S strain. An in vitro metabolism study indicated that there was no difference between strains in the overall rate of metabolism of trans -[ 14 C]permethrin. The evidence obtained supports the conclusion that several resistance factors are involved but that decreased sensitivity of the nervous system to the action of pyrethroids is the principal mechanism of resistance in the 147-R strain." @default.
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- W2077508052 date "1981-06-01" @default.
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- W2077508052 title "Absence of enhanced detoxication of permethrin in pyrethroid-resistant house flies" @default.
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- W2077508052 doi "https://doi.org/10.1016/0048-3575(81)90006-7" @default.
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