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• W2077514098 abstract "Immunodeficient mice are becoming invaluable tools in human stem cell and tumor research. In this study, we generated Rag-2/Jak3 double-deficient (Rag-2 −/− Jak3 −/− ) mice with a C57/BL6 and Balb/c genetic background and compared the human lymphohematopoietic cell engraftment rate. Human cord blood-derived CD34 + hematopoietic stem cells were successfully engrafted into Balb/c Rag-2 −/− Jak3 −/− mice; however, the engraftment rate was far lower in C57/BL6 Rag-2 −/− Jak3 −/− mice. Transplantation of human peripheral blood mononuclear cells resulted in the same tendency. Thus, a Balb/c background offers superior engraftment capacity than a C57/BL6 background and provides an attractive model for human hematopoietic cell engraftment." @default.
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• W2077514098 date "2011-01-01" @default.
• W2077514098 modified "2023-10-16" @default.
• W2077514098 title "Comparative Study of Human Hematopoietic Cell Engraftment into Balb/c and C57BL/6 Strain of Rag-2/Jak3 Double-Deficient Mice" @default.
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• W2077514098 doi "https://doi.org/10.1155/2011/539748" @default.
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