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- W2077527679 abstract "A synthesis of orthogonally protected L-threo-beta-hydroxyasparagine from L-aspartic acid is reported. Iodocyclization of 3-benzoylaminoaspartic acid provided an intermediate oxazoline dicarboxylate that was efficiently hydrolyzed to L-threo-beta-hydroxyaspartic acid. The synthetic route for conversion of the free beta-hydroxy-alpha-amino acid into the target compound is highly efficient and amenable to preparation various orthogonally protected asparagine derivatives, on a multiple gram scale." @default.
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- W2077527679 date "2007-06-01" @default.
- W2077527679 modified "2023-09-25" @default.
- W2077527679 title "An Operationally Simple and Efficient Synthesis of Orthogonally Protected <scp>l</scp>-<i>threo</i>-β-Hydroxyasparagine" @default.
- W2077527679 doi "https://doi.org/10.1055/s-2007-982544" @default.
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