FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077534129> ?p ?o ?g. }

• W2077534129 endingPage "953" @default.
• W2077534129 startingPage "946" @default.
• W2077534129 abstract "The effect of 60-min constant iv infusions of αhuman atrial natriuretic peptide (αhANP; 200 μg), sufficient to increasethe steady state venous plasma αhANP concentration to levels found inpatients with some circulatory disorders, was studied in six normal men equilibrated on a high sodium diet (200 mmol daily) and again when equilibrated on a low sodium intake (10 mmol daily). In each instance, the responsestoαhANP were compared to those to control infusions given on the preceding day. The mean steady state plasma immunoreactive ANP concentration during the infusions was 320 pmol/liter and was the same during both diets. Thus, the MCR of αhANP was unaffected by major changes in sodium intake. Compared to control day observations, infusions of ahANP induced a more than 3-fold increase in sodium excretion and at least a 2-fold increase in urine volume and calcium and magnesium excretion in subjects ingesting 200 mmol sodium daily. During the low sodium diet, αhANP was still diuretic and induced comparable magnesium excretion, but the natriuresis was only 11% of that during the high salt diet. No significant changes in blood pressure or heart rate occurred during αhANP infusions during either diet, although during both diets there was a significant rise in plasma norepinephrine (P < 0.02), which persisted well beyond the disappearance of immunoreactive ANP from plasma. Despite this sympathetic activation, renin and aldosterone production was reduced by αhANP. During low salt intake, αhANP significantly decreased PRA (mean pretreatment, 1.79; posttreatment, 1.25 nmol/liter/h; P < 0.03), angiotensin II (mean pretreatment, 49; posttreatment, 28 pmol/liter; P < 0.008), and plasma aldosterone (mean pretreatment, 554; posttreatment 307 pmol/liter; P < 0.007), whereas values during control infusions did not change. Similar percent decreases in PRA and aldosterone also occurred during the high salt diet. Plasmacortisol and arginine vasopressin did not change during the ahANP infusionson either diet. We conclude that steady state levels of αhANP in plasma, similar to those in patients with some circulatory disorders, significantly increasesodium excretion and inhibit all elements of the renin-angiotensin-aldosterone system. The natriuretic, but not the hormonal or chronotropic, effects of αhANP are reduced by sodium depletion in normal man." @default.
• W2077534129 created "2016-06-24" @default.
• W2077534129 creator A5003644228 @default.
• W2077534129 creator A5015432494 @default.
• W2077534129 creator A5032030679 @default.
• W2077534129 creator A5040806060 @default.
• W2077534129 creator A5068326299 @default.
• W2077534129 creator A5088096561 @default.
• W2077534129 date "1986-10-01" @default.
• W2077534129 modified "2023-10-14" @default.
• W2077534129 title "Renal, Hemodynamic, and Hormonal Responses to Atrial Natriuretic Peptide Infusions in Normal Man, and Effect of Sodium Intake*" @default.
• W2077534129 cites W193058689 @default.
• W2077534129 cites W1948371562 @default.
• W2077534129 cites W1963989474 @default.
• W2077534129 cites W1974946514 @default.
• W2077534129 cites W1989514987 @default.
• W2077534129 cites W2012041356 @default.
• W2077534129 cites W2015283139 @default.
• W2077534129 cites W202078600 @default.
• W2077534129 cites W2021479380 @default.
• W2077534129 cites W2027205055 @default.
• W2077534129 cites W2030556921 @default.
• W2077534129 cites W2052794916 @default.
• W2077534129 cites W2063413405 @default.
• W2077534129 cites W2080132669 @default.
• W2077534129 cites W2137639534 @default.
• W2077534129 cites W2209840865 @default.
• W2077534129 cites W2407211367 @default.
• W2077534129 cites W2410182003 @default.
• W2077534129 cites W2411728052 @default.
• W2077534129 cites W2417239947 @default.
• W2077534129 cites W2418017927 @default.
• W2077534129 cites W2409568773 @default.
• W2077534129 cites W2473816902 @default.
• W2077534129 doi "https://doi.org/10.1210/jcem-63-4-946" @default.
• W2077534129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2943757" @default.
• W2077534129 hasPublicationYear "1986" @default.
• W2077534129 type Work @default.
• W2077534129 sameAs 2077534129 @default.
• W2077534129 citedByCount "141" @default.
• W2077534129 countsByYear W20775341292013 @default.
• W2077534129 countsByYear W20775341292014 @default.
• W2077534129 countsByYear W20775341292018 @default.
• W2077534129 countsByYear W20775341292020 @default.
• W2077534129 countsByYear W20775341292023 @default.
• W2077534129 crossrefType "journal-article" @default.
• W2077534129 hasAuthorship W2077534129A5003644228 @default.
• W2077534129 hasAuthorship W2077534129A5015432494 @default.
• W2077534129 hasAuthorship W2077534129A5032030679 @default.
• W2077534129 hasAuthorship W2077534129A5040806060 @default.
• W2077534129 hasAuthorship W2077534129A5068326299 @default.
• W2077534129 hasAuthorship W2077534129A5088096561 @default.
• W2077534129 hasConcept C10146269 @default.
• W2077534129 hasConcept C126322002 @default.
• W2077534129 hasConcept C134018914 @default.
• W2077534129 hasConcept C138976137 @default.
• W2077534129 hasConcept C174459258 @default.
• W2077534129 hasConcept C178790620 @default.
• W2077534129 hasConcept C185592680 @default.
• W2077534129 hasConcept C198710026 @default.
• W2077534129 hasConcept C2778069365 @default.
• W2077534129 hasConcept C2778514916 @default.
• W2077534129 hasConcept C2778525890 @default.
• W2077534129 hasConcept C2779918671 @default.
• W2077534129 hasConcept C2908929049 @default.
• W2077534129 hasConcept C513476851 @default.
• W2077534129 hasConcept C537181965 @default.
• W2077534129 hasConcept C56191518 @default.
• W2077534129 hasConcept C71315377 @default.
• W2077534129 hasConcept C71924100 @default.
• W2077534129 hasConcept C84393581 @default.
• W2077534129 hasConceptScore W2077534129C10146269 @default.
• W2077534129 hasConceptScore W2077534129C126322002 @default.
• W2077534129 hasConceptScore W2077534129C134018914 @default.
• W2077534129 hasConceptScore W2077534129C138976137 @default.
• W2077534129 hasConceptScore W2077534129C174459258 @default.
• W2077534129 hasConceptScore W2077534129C178790620 @default.
• W2077534129 hasConceptScore W2077534129C185592680 @default.
• W2077534129 hasConceptScore W2077534129C198710026 @default.
• W2077534129 hasConceptScore W2077534129C2778069365 @default.
• W2077534129 hasConceptScore W2077534129C2778514916 @default.
• W2077534129 hasConceptScore W2077534129C2778525890 @default.
• W2077534129 hasConceptScore W2077534129C2779918671 @default.
• W2077534129 hasConceptScore W2077534129C2908929049 @default.
• W2077534129 hasConceptScore W2077534129C513476851 @default.
• W2077534129 hasConceptScore W2077534129C537181965 @default.
• W2077534129 hasConceptScore W2077534129C56191518 @default.
• W2077534129 hasConceptScore W2077534129C71315377 @default.
• W2077534129 hasConceptScore W2077534129C71924100 @default.
• W2077534129 hasConceptScore W2077534129C84393581 @default.
• W2077534129 hasIssue "4" @default.
• W2077534129 hasLocation W20775341291 @default.
• W2077534129 hasLocation W20775341292 @default.
• W2077534129 hasOpenAccess W2077534129 @default.
• W2077534129 hasPrimaryLocation W20775341291 @default.
• W2077534129 hasRelatedWork W2052305290 @default.
• W2077534129 hasRelatedWork W2066410990 @default.
• W2077534129 hasRelatedWork W2300081670 @default.

• next